Motohiro T, Koga T, Shimada Y, Tomita S, Fujimoto T, Nishiyama T, Tominaga K, Yamashita F, Takajo N, Nakano M
Jpn J Antibiot. 1987 Apr;40(4):883-900.
Newly developed cefuzoname (CZON) was tested in 21 children and serum and urinary concentration and urinary recovery rates were determined. To 9 cases, 3 groups of 3 cases each, CZON was given at 10, 20 or 40 mg/kg one shot intravenously, and to 12 cases, 3 groups of 5, 3, 4 cases each, 10, 20 or 40 mg/kg was drip-infused over 1 hour. To 1 case of purulent meningitis 55.6 mg/kg was given one shot intravenously and concentrations in cerebrospinal fluid (CSF) and serum were measured. In 37 pediatric patients comprising 1 with tonsillitis, 24 with pneumonia, 1 with purulent meningitis and bacteremia, 7 with urinary tract infection, and 1 each with staphylococcal scalded skin syndrome, purulent lymphadenitis, periarthritis of jaw joint, maxillary sinusitis and orbital abscess, CZON was tried at 21.6 mg/kg (mean) per dose, 3 or 4 doses daily, one shot intravenously, for 7 days (mean). The clinical efficacy and antibacterial effectiveness were investigated. Also, the side effects were investigated and clinical laboratory tests done in the 37 pediatric cases plus 6 cases in which CZON was used but which were excluded from the efficacy analysis because they did not involve infections. The following is a summary of the results: 1. To 3 groups of 3 children each, 10, 20 or 40 mg/kg of CZON was given one shot intravenously. In each case the maximum serum concentration was observed at 5 min. after injection, and mean values of 3 groups with 10, 20 and 40 mg/kg dosing were 57.1, 147.2 and 316.7 mcg/ml respectively, indicating a dose-dependent response among the 3 groups. Mean half-lives were 0.83, 1.10 and 0.79 hours for 10, 20 and 40 mg/kg groups, respectively. The 10 mg/kg and the 40 mg/kg groups showed similar half-lives but the half-life of the 20 mg/kg group was a little longer than those of the other 2. 2. CZON was drip-infused over 1 hour to a total of 12 children divided into 3 groups of 5, 3 and 4 children at dose levels of 10, 20 and 40 mg/kg, respectively.(ABSTRACT TRUNCATED AT 400 WORDS)
对新开发的头孢唑肟（CZON）在21名儿童中进行了测试，并测定了血清和尿液浓度以及尿回收率。对9例儿童，分成3组，每组3例，分别以10、20或40mg/kg静脉注射一剂CZON；对12例儿童，分成3组，分别为5、3、4例，以10、20或40mg/kg在1小时内静脉滴注。对1例化脓性脑膜炎患儿静脉注射一剂55.6mg/kg，并测定脑脊液（CSF）和血清中的浓度。在37例儿科患者中，包括1例扁桃体炎、24例肺炎、1例化脓性脑膜炎合并菌血症、7例尿路感染，以及各1例葡萄球菌烫伤样皮肤综合征、化脓性淋巴结炎、颞颌关节炎、上颌窦炎和眼眶脓肿患者，以每剂21.6mg/kg（平均）、每日3或4剂、静脉注射一剂，治疗7天（平均）。研究了临床疗效和抗菌效果。此外，对这37例儿科病例以及6例使用了CZON但因未涉及感染而被排除在疗效分析之外的病例进行了副作用调查和临床实验室检查。以下是结果总结：1. 对3组儿童，每组3名，分别静脉注射一剂10、20或40mg/kg的CZON。在每种情况下，注射后5分钟观察到最大血清浓度，10、20和40mg/kg给药组的平均值分别为57.1、147.2和316.7mcg/ml，表明三组之间存在剂量依赖性反应。10mg/kg、20mg/kg和40mg/kg组的平均半衰期分别为0.83、1.10和0.79小时。10mg/kg组和40mg/kg组的半衰期相似，但20mg/kg组的半衰期比其他两组略长。2. 对总共12名儿童，分成3组，分别为5、3和4名儿童，以10、20和40mg/kg的剂量水平在1小时内静脉滴注CZON。（摘要截断于400字）
