Department of Cardiothoracic Surgery, Third Xiangya Hospital, Central South University, Changsha, China.
Clinical Research Center, Third Xiangya Hospital, Central South University, Changsha, China.
Front Endocrinol (Lausanne). 2022 Sep 5;13:1001223. doi: 10.3389/fendo.2022.1001223. eCollection 2022.
Trauma is a well-known risk factor for many disease, but the effect of trauma on respiratory disease is unclarified. In the present study, we aimed to evaluate the association between trauma and respiratory disease.
Using both United Kingdom biobank and Finnish biobank genome-wide association study data (GWAS), we performed a two-sample Mendelian randomization (MR) analysis to evaluate the relationship between trauma and respiratory disease. We used four methods including inverse-variance weighted (IVW), weighted median, Maximum likelihood, and MR-Egger in this MR analysis. The IVW MR was selected as the main method. We also performed multivariable Mendelian randomization (MVMR) to simultaneously assess the independent impact of trauma exposure on respiratory disease.
In the main two-sample MR analysis, trauma exposure was significantly associated with increased risk of respiratory disease (OR 1.15, 95%CI: 1.05-1.25). Besides, there was no heterogeneity and horizontal pleiotropy observed in the sensitivity analysis. After adjusting for pack years of smoking and body mass index (BMI), trauma exposure retained its association with respiratory disease (OR, 1.13, 95%CI, 1.04-1.23 adjusted by pack years of smoking; and OR, 1.11, 95%CI, 1.04-1.18 adjusted by BMI).
Our study discovered the association between trauma exposure and the increased risk of respiratory disease, suggesting the prevention and treatment with trauma to reduce the risk of respiratory disease.
创伤是许多疾病的已知危险因素，但创伤对呼吸疾病的影响尚不清楚。在本研究中，我们旨在评估创伤与呼吸疾病之间的关系。
我们使用英国生物库和芬兰生物库的全基因组关联研究数据（GWAS）进行了两样本孟德尔随机化（MR）分析，以评估创伤与呼吸疾病之间的关系。我们在这项 MR 分析中使用了四种方法，包括逆方差加权（IVW）、加权中位数、最大似然和 MR-Egger。IVW-MR 被选为主要方法。我们还进行了多变量孟德尔随机化（MVMR），以同时评估创伤暴露对呼吸疾病的独立影响。
在主要的两样本 MR 分析中，创伤暴露与呼吸疾病风险增加显著相关（OR 1.15，95%CI：1.05-1.25）。此外，敏感性分析中未观察到异质性和水平偏倚。在调整吸烟包年数和体重指数（BMI）后，创伤暴露仍然与呼吸疾病相关（调整吸烟包年数后 OR，1.13，95%CI，1.04-1.23；调整 BMI 后 OR，1.11，95%CI，1.04-1.18）。
我们的研究发现了创伤暴露与呼吸疾病风险增加之间的关联，表明预防和治疗创伤以降低呼吸疾病的风险。
