Berhili Soufiane, Guerrouaz Mohammed Amine, Terrab Fatima Zahra, Moukhlissi Mohammed, Mezouar Loubna
Radiation Oncology, Faculty of Medicine, Mohammed First University, Oujda, MAR.
Radiation Oncology, Hassan II Center of Oncology, Mohammed VI University Hospital, Oujda, MAR.
Cureus. 2022 Aug 4;14(8):e27678. doi: 10.7759/cureus.27678. eCollection 2022 Aug.
Radical prostatectomy in high-risk prostate cancer patients has long been followed by immediate adjuvant radiotherapy (IART) to increase biochemical relapse-free survival. However, the increased urinary and digestive radio-induced toxicities have raised questions about the safety of delaying radiotherapy until the occurrence of biochemical or clinical relapse. Recently, early salvage radiotherapy (ESRT) has been compared to IART, and results found equivalence in terms of efficiency outcomes, but increased toxicity was noted in patients receiving IART, leading to the proposal of ESRT as the new standard of care in high-risk patients after surgery. However, several confounding points are discussed in the present review regarding the methodology and results of these recent trials. Further follow-up is necessary to detect possible long-term advantages of one radiotherapy timing over the other.
长期以来，高危前列腺癌患者在根治性前列腺切除术后一直紧接着进行即刻辅助放疗（IART），以提高无生化复发生存率。然而，放疗导致的泌尿和消化毒性增加，引发了人们对将放疗推迟至生化或临床复发出现时进行的安全性的质疑。最近，早期挽救性放疗（ESRT）已与IART进行了比较，结果发现在疗效方面二者相当，但接受IART的患者毒性增加，这使得ESRT被提议作为高危患者术后新的护理标准。然而，本综述讨论了这些近期试验在方法和结果方面的几个混杂点。有必要进行进一步随访，以检测一种放疗时机相对于另一种放疗时机可能存在的长期优势。
