Maurya Priyanka, Saklani Ravi, Singh Samipta, Nisha Raquibun, Mishra Nidhi, Singh Priya, Pal Ravi Raj, Kumar Abhiram, Chourasia Manish K, Saraf Shubhini A
Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University (A Central University) Vidya Vihar, Lucknow, 226025, India.
Department of Pharmaceutics and Pharmacokinetics, CSIR-Central Drug Research Institute Sector 10, Jankipuram Extension, Lucknow, 226031, India.
Nanomedicine (Lond). 2022 Oct;17(24):1819-1831. doi: 10.2217/nnm-2021-0468. Epub 2022 Sep 22.
To assess the targeting ability of hybrid nanosystems functionalized with folate. It also aimed to reduce stomach intolerance by substituting the oral route for parenteral delivery. The nanosystems, prepared by nanoprecipitation technique, utilized a one-step method to prepare nanoparticles followed by surface functionalization through adsorption. The prepared nanosystems underwent physical characterization, and evaluations. The nanosystems were effective in targeting the alveolar macrophages. Ethionamide was released from the formulation over 5 days. Fourier-transform infrared results proved the structural characteristics, and the positive charge further improved the targeting efficacy on the functionalized system. The hybrid formulation improved the release characteristics. Reduction in dosing frequency due to prolonged release improves compliance with the dosage regimen.
评估用叶酸功能化的混合纳米系统的靶向能力。它还旨在通过用肠胃外给药替代口服途径来降低胃部不耐受性。通过纳米沉淀技术制备的纳米系统采用一步法制备纳米颗粒，随后通过吸附进行表面功能化。对制备的纳米系统进行了物理表征和评估。这些纳米系统在靶向肺泡巨噬细胞方面是有效的。乙硫异烟胺在5天内从制剂中释放出来。傅里叶变换红外结果证明了结构特征，正电荷进一步提高了功能化系统的靶向效果。混合制剂改善了释放特性。由于延长释放导致给药频率降低，提高了对给药方案的依从性。
