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通过分发海洛因注射工具减少海洛因成瘾者的高危药物使用行为:一项初步准实验研究。

Heroin pipe distribution to reduce high-risk drug consumption behaviors among people who use heroin: a pilot quasi-experimental study.

机构信息

Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA, USA.

The People's Harm Reduction Alliance, 1959 NE Pacific St., Box 356423, Seattle, WA, 98195, USA.

出版信息

Harm Reduct J. 2022 Sep 22;19(1):103. doi: 10.1186/s12954-022-00685-7.

Abstract

BACKGROUND

Heroin pipe distribution may encourage people who use heroin (PWUH) to transition from injecting to smoking heroin, reducing harms associated with injection drug use. A syringe services program (SSP) in Seattle, Washington, led by people who use drugs developed a heroin pipe distribution program.

METHODS

We conducted a pretest-posttest quasi-experimental study to evaluate the impact of heroin pipe distribution on drug consumption behaviors among PWUH between March and December 2019. SSP clients were surveyed during three weeklong timepoints before and four weeklong timepoints after heroin pipe distribution. Primary outcomes were change in proportion of SSP clients who exclusively injected heroin, exclusively smoked heroin, and both injected and smoked heroin in the past seven days comparing the pre- and post-intervention periods.

RESULTS

Across the seven observation timepoints, 694 unique respondents completed 957 surveys. Multiple responses from a single respondent in a given period were collapsed, resulting in 360 pre-intervention and 430 post-intervention records. Heroin use was reported in over half of pre-intervention (56%, 201/360) and post-intervention records (58%, 251/430). Compared to pre-intervention behaviors, the proportion of respondents who exclusively injected heroin was lower after the start of heroin pipe distribution (32%, 80/251 vs 43%, 86/201, p = 0.02), while the proportion of respondents who both injected and smoked heroin was higher (45%, 113/251 vs 36%, 72/201, p = 0.048). Just under half (44%, 110/251) of respondents who used heroin during the post-intervention period used a heroin pipe obtained from the SSP, of which 34% (37/110) reported heroin pipe distribution had reduced their heroin injection frequency. Self-reported hospitalization for a pulmonary cause was not associated with using a heroin pipe.

CONCLUSIONS

The proportion of SSP clients who exclusively injected heroin was lower after implementation of heroin pipe distribution. Randomized studies with longer follow-up are needed to investigate whether heroin pipe distribution reduces heroin injection and improves health outcomes associated with drug use. Limited intervention exposure, loss to follow-up, and pipe availability from other sources pose methodological challenges to evaluations of route transition interventions in community settings. This pilot highlights the potential for organizations led by people who use drugs to develop, implement, and evaluate novel public health programming.

摘要

背景

海洛因烟斗分发可能会鼓励使用海洛因的人(PWUH)从注射过渡到吸食海洛因,从而减少与注射吸毒相关的危害。华盛顿州西雅图的一个由吸毒者领导的注射器服务项目(SSP)制定了一项海洛因烟斗分发计划。

方法

我们进行了一项预-后测试准实验研究,以评估 2019 年 3 月至 12 月期间海洛因烟斗分发对 PWUH 药物消费行为的影响。在海洛因烟斗分发前后三个为期一周的时间点和四个为期一周的时间点对 SSP 客户进行了调查。主要结果是在干预前后期间,比较 SSP 客户中过去七天内仅注射海洛因、仅吸食海洛因以及同时注射和吸食海洛因的比例变化。

结果

在七个观察时间点中,694 名独特的受访者完成了 957 份调查。在给定时期内,从单个受访者获得的多个回复被合并,导致 360 份干预前记录和 430 份干预后记录。在干预前(56%,201/360)和干预后记录(58%,251/430)中均报告了海洛因使用。与干预前的行为相比,在开始分发海洛因烟斗后,仅注射海洛因的受访者比例较低(32%,80/251 与 43%,86/201,p=0.02),而同时注射和吸食海洛因的受访者比例较高(45%,113/251 与 36%,72/201,p=0.048)。在干预后期间使用海洛因的受访者中,有近一半(44%,110/251)使用了从 SSP 获得的海洛因烟斗,其中 34%(37/110)报告说,分发海洛因烟斗减少了他们的海洛因注射频率。因肺部疾病住院与使用海洛因烟斗无关。

结论

实施海洛因烟斗分发后,仅注射海洛因的 SSP 客户比例降低。需要进行具有更长随访时间的随机研究,以调查海洛因烟斗分发是否会减少海洛因注射并改善与药物使用相关的健康结果。在社区环境中,干预暴露有限、随访丢失以及其他来源的烟斗可用性给评估途径转换干预措施带来了方法学挑战。本试点强调了由吸毒者领导的组织制定、实施和评估新的公共卫生方案的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d219/9494826/95315532cc7c/12954_2022_685_Fig1_HTML.jpg

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