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人胎盘血流的控制

Control of human placental blood flow.

作者信息

Howard R B

出版信息

Med Hypotheses. 1987 May;23(1):51-8. doi: 10.1016/0306-9877(87)90180-0.

DOI:10.1016/0306-9877(87)90180-0
PMID:3614003
Abstract

An overall scheme is proposed for the control of blood flows in both fetal and maternal circulations of the human placenta. The first part of the hypothesis is that fetoplacental vascular resistance is controlled locally by a reversible hypoxic fetoplacental vasoconstriction (HFPV) in response to reduced local maternoplacental oxygen delivery. Also suggested is humoral limitation of the extent of HFPV by substances circulating in hypoxic fetal blood. Secondly, it is hypothesized that maternoplacental vascular resistance is controlled humorally by release of hormones into maternal blood from the fetoplacental unit. Finally, it is proposed that chronic local maternoplacental ischemia associated with placental "aging" can induce an irreversible fetoplacental vasoconstriction by a mechanism different from HFPV in order to permanently shut down fetal blood flow to the area(s) affected.

摘要

本文提出了一个控制人类胎盘胎儿和母体循环中血流的总体方案。该假说的第一部分是,胎儿胎盘血管阻力由局部可逆性缺氧胎儿胎盘血管收缩(HFPV)局部控制,以应对局部母体胎盘氧输送减少。还提出,缺氧胎儿血液中循环的物质对HFPV的程度有体液限制作用。其次,假说认为母体胎盘血管阻力由胎儿胎盘单位向母体血液中释放激素进行体液控制。最后,提出与胎盘“老化”相关的慢性局部母体胎盘缺血可通过一种不同于HFPV的机制诱导不可逆的胎儿胎盘血管收缩,从而永久性地阻断胎儿血流至受影响区域。

相似文献

1
Control of human placental blood flow.人胎盘血流的控制
Med Hypotheses. 1987 May;23(1):51-8. doi: 10.1016/0306-9877(87)90180-0.
2
Hypoxia-induced fetoplacental vasoconstriction in perfused human placental cotyledons.灌注人胎盘小叶中缺氧诱导的胎儿-胎盘血管收缩
Am J Obstet Gynecol. 1987 Nov;157(5):1261-6. doi: 10.1016/s0002-9378(87)80307-1.
3
Hypoxic fetoplacental vasoconstriction in humans is mediated by potassium channel inhibition.人类胎儿胎盘的缺氧性血管收缩是由钾通道抑制介导的。
Am J Physiol Heart Circ Physiol. 2002 Dec;283(6):H2440-9. doi: 10.1152/ajpheart.01033.2001. Epub 2002 Aug 22.
4
Rho-kinase inhibition attenuates acute hypoxic fetoplacental vasoconstriction in the rat.Rho-kinase 抑制减轻大鼠急性低氧胎盘中血管收缩。
Physiol Res. 2012;61 Suppl 2(Suppl 2):S43-8. doi: 10.33549/physiolres.932398.
5
Hypoxemic fetoplacental vasoconstriction: a graduated response to reduced oxygen conditions in the human placenta.低氧血症性胎儿-胎盘血管收缩:对人类胎盘氧气减少状况的分级反应。
Anesth Analg. 2006 Aug;103(2):439-42, table of contents. doi: 10.1213/01.ane.0000222468.76942.d8.
6
Voltage-gated calcium channels mediate hypoxic vasoconstriction in the human placenta.电压门控钙通道介导人胎盘的缺氧性血管收缩。
Placenta. 2006 Sep-Oct;27(9-10):1030-3. doi: 10.1016/j.placenta.2005.10.006. Epub 2005 Dec 20.
7
Chronic hypoxia increases fetoplacental vascular resistance and vasoconstrictor reactivity in the rat.慢性缺氧会增加大鼠胎盘血管阻力和血管收缩反应性。
Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1638-44. doi: 10.1152/ajpheart.01120.2007. Epub 2008 Feb 29.
8
The dynamic placenta: I. Hypothetical model of a placental mechanism matching local fetal blood flow to local intervillus oxygen delivery.动态胎盘:I. 一种使局部胎儿血流与局部绒毛间隙氧输送相匹配的胎盘机制的假设模型。
Med Hypotheses. 2004;62(4):511-9. doi: 10.1016/j.mehy.2003.10.025.
9
Regulation of fetoplacental vascular bed by hypoxia.缺氧对胎-胎盘血管床的调节。
Physiol Res. 2009;58 Suppl 2:S87-S94. doi: 10.33549/physiolres.931922.
10
Pregestational diabetes increases fetoplacental vascular resistance in rats.孕前糖尿病增加大鼠胎盘中血管阻力。
Placenta. 2018 Mar;63:32-38. doi: 10.1016/j.placenta.2018.01.008. Epub 2018 Jan 31.

引用本文的文献

1
Antenatal maternal hypoxic stress: adaptations of the placental renin-angiotensin system in the mouse.产前母体低氧应激:小鼠胎盘肾素-血管紧张素系统的适应。
Placenta. 2011 Feb;32(2):134-9. doi: 10.1016/j.placenta.2010.11.004. Epub 2010 Dec 3.
2
Differential localization of endothelin ETA and ETB binding sites in human placenta.内皮素ETA和ETB结合位点在人胎盘中的差异定位。
Br J Pharmacol. 1993 Jun;109(2):544-52. doi: 10.1111/j.1476-5381.1993.tb13605.x.