Eilsberger Friederike, Noltenius Friederike Elisabeth, Librizzi Damiano, Wessendorf Joel, Luster Markus, Hoch Stephan, Pfestroff Andreas
Department of Nuclear Medicine, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, Germany.
Department of Otolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, Germany.
Biomedicines. 2022 Aug 27;10(9):2095. doi: 10.3390/biomedicines10092095.
Neoplasms in the head and neck region possess higher glycolytic activity than normal tissue, showing increased glucose metabolism. F-18-Flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can identify an unknown primary tumor (CUP).
The aim of this study was to assess the real-life performance of F-18-FDG-PET/CT in detecting primary sites in patients with cervical lymph node metastasis of CUP.
A retrospective data analysis of 31 patients who received FDG-PET/CT between June 2009 and March 2015 in a CUP context with histologically confirmed cervical lymph node metastasis was included.
In 48% of the patients (15/31), PET/CT showed suspicious tracer accumulation. In 52% of the patients (16/31), there was no suspicious radiotracer uptake, which was confirmed by the lack of identification of any primary tumor in 10 cases until the end of follow-up. FDG-PET/CT had a sensitivity of 67%, specificity of 91%, PPV of 92%, and NPV of 63% in detecting the primary tumor. Additionally, PET/CT showed suspicious tracer accumulation according to further metastasis in 32% of the patients (10/31).
FDG-PET/CT imaging is a useful technique for primary tumor detection in patients in a cervical CUP context. Furthermore, it provides information on the ulterior metastasis of the disease.
头颈部肿瘤的糖酵解活性高于正常组织，表现为葡萄糖代谢增加。F-18-氟脱氧葡萄糖（FDG）正电子发射断层扫描/计算机断层扫描（PET/CT）能够识别未知原发肿瘤（CUP）。
本研究旨在评估F-18-FDG-PET/CT在检测CUP颈部淋巴结转移患者原发部位中的实际应用表现。
对2009年6月至2015年3月期间31例接受FDG-PET/CT检查、组织学确诊为CUP颈部淋巴结转移的患者进行回顾性数据分析。
48%的患者（15/31）PET/CT显示有可疑示踪剂聚集。52%的患者（16/31）无可疑放射性示踪剂摄取，其中10例在随访结束时仍未发现任何原发肿瘤得以证实。FDG-PET/CT检测原发肿瘤的敏感性为67%，特异性为91%，阳性预测值为92%，阴性预测值为63%。此外，32%的患者（10/31）PET/CT根据进一步转移情况显示有可疑示踪剂聚集。
FDG-PET/CT成像对于CUP颈部患者的原发肿瘤检测是一种有用的技术。此外，它还能提供有关该疾病远处转移的信息。
