Di Rauso Giulia, Cavallieri Francesco, Campanini Isabella, Gessani Annalisa, Fioravanti Valentina, Feletti Alberto, Damiano Benedetta, Scaltriti Sara, Bardi Elisa, Corni Maria Giulia, Antonelli Francesca, Rispoli Vittorio, Cavalleri Francesca, Molinari Maria Angela, Contardi Sara, Menozzi Elisa, Puzzolante Annette, Rossi Jessica, Meletti Stefano, Biagini Giuseppe, Pavesi Giacomo, Fraix Valerie, Lusuardi Mirco, Fraternali Alessandro, Versari Annibale, Budriesi Carla, Moro Elena, Merlo Andrea, Valzania Franco
Neurology Unit, Neuromotor & Rehabilitation Department, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, Italy.
Neurology Unit, Neuroscience Head Neck Department, Ospedale Civile Baggiovara (OCB) Hospital, Azienda Ospedaliero-Universitaria di Modena, 41126 Modena, Italy.
Biomedicines. 2022 Sep 7;10(9):2214. doi: 10.3390/biomedicines10092214.
Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment in advanced Parkinson's Disease (PD). However, the effects of STN-DBS on freezing of gait (FOG) are still debated, particularly in the long-term follow-up (≥5-years). The main aim of the current study is to evaluate the long-term effects of STN-DBS on FOG. Twenty STN-DBS treated PD patients were included. Each patient was assessed before surgery through a detailed neurological evaluation, including FOG score, and revaluated in the long-term (median follow-up: 5-years) in different stimulation and drug conditions. In the long term follow-up, FOG score significantly worsened in the off-stimulation/off-medication condition compared with the pre-operative off-medication assessment (z = -1.930; = 0.05) but not in the on-stimulation/off-medication (z = -0.357; = 0.721). There was also a significant improvement of FOG at long-term assessment by comparing on-stimulation/off-medication and off-stimulation/off-medication conditions (z = -2.944; = 0.003). These results highlight the possible beneficial long-term effects of STN-DBS on FOG.
双侧丘脑底核脑深部电刺激术（STN-DBS）是晚期帕金森病（PD）的一种有效治疗方法。然而，STN-DBS对冻结步态（FOG）的影响仍存在争议，尤其是在长期随访（≥5年）中。本研究的主要目的是评估STN-DBS对FOG的长期影响。纳入了20例接受STN-DBS治疗的PD患者。每位患者在手术前均通过详细的神经学评估进行评估，包括FOG评分，并在长期（中位随访时间：5年）内于不同刺激和药物状态下进行重新评估。在长期随访中，与术前停药评估相比，刺激关闭/药物停用状态下的FOG评分显著恶化（z = -1.930；P = 0.05），但在刺激开启/药物停用状态下未出现恶化（z = -0.357；P = 0.721）。通过比较刺激开启/药物停用和刺激关闭/药物停用状态，长期评估时FOG也有显著改善（z = -2.944；P = 0.003）。这些结果突出了STN-DBS对FOG可能的长期有益影响。
