Tani Jowy, Yang Yao-Hua, Chen Chao-Min, Siow Co Yih, Chang Tsui-San, Yang Kai, Yao Jack, Hu Chaur-Jong, Sung Jia-Ying
Department of Neurology, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan.
Biomed Innovation Center, Wan Fang Hospital, Taipei Medical University, Taipei 116079, Taiwan.
Diagnostics (Basel). 2022 Sep 16;12(9):2242. doi: 10.3390/diagnostics12092242.
The present study proposes a cognitive prosthesis device for face memory impairment as a proof-of-concept for the domain-specific cognitive prosthesis. Healthy subjects (n = 6) and a patient with poor face memory were enrolled. An acquaintance face recognition test with and without the use of cognitive prosthesis for face memory impairment, face recognition tests, quality of life, neuropsychological assessments, and machine learning performance of the cognitive prosthesis were followed-up throughout four weeks of real-world device use by the patient. The healthy subjects had an accuracy of 92.38 ± 4.41% and reaction time of 1.27 ± 0.12 s in the initial attempt of the acquaintance face recognition test, which changed to 80.48 ± 6.23% (p = 0.06) and 2.11 ± 0.20 s (p < 0.01) with prosthesis use. The patient had an accuracy of 74.29% and a reaction time of 6.65 s, which improved to 94.29% and 3.28 s with prosthesis use. After four weeks, the patient’s unassisted accuracy and reaction time improved to 100% and 1.23 s. Functional MRI study revealed activation of the left superior temporal lobe during face recognition task without prosthesis use and activation of the right precentral motor area with prosthesis use. The prosthesis could improve the patient’s performance by bypassing the brain area inefficient for facial recognition and employing the area more efficiently for the cognitive task.
本研究提出了一种用于面部记忆障碍的认知假体装置，作为特定领域认知假体的概念验证。招募了健康受试者（n = 6）和一名面部记忆较差的患者。在患者实际使用该装置的四周时间里，随访了在使用和不使用用于面部记忆障碍的认知假体情况下的熟人面部识别测试、面部识别测试、生活质量、神经心理学评估以及认知假体的机器学习性能。健康受试者在熟人面部识别测试的初次尝试中准确率为92.38±4.41%，反应时间为1.27±0.12秒，使用假体后分别变为80.48±6.23%（p = 0.06）和2.11±0.20秒（p < 0.01）。该患者的准确率为74.29%，反应时间为6.65秒，使用假体后提高到94.29%和3.28秒。四周后，患者在无辅助情况下的准确率和反应时间分别提高到100%和1.23秒。功能磁共振成像研究显示，在不使用假体进行面部识别任务时，左侧颞上叶激活，而使用假体时右侧中央前运动区激活。该假体可以绕过对面部识别效率低下的脑区，更有效地利用该区域进行认知任务，从而提高患者的表现。
