SARS-CoV-2 感染导致再生障碍性贫血/阵发性睡眠性血红蛋白尿症患者全血细胞减少症：病例报告。
Pancytopenia in a Case of Aplastic Anaemia/Paroxysmal Nocturnal Haemoglobinuria Unmasked by SARS-CoV-2 Infection: A Case Report.
机构信息
Department of Medicine and Medical Specialties, A. Cardarelli Hospital, 80131 Naples, Italy.
Department of Acute Internal Medicine, Royal Victoria Infirmary, Newcastle NE1 4LP, UK.
出版信息
Medicina (Kaunas). 2022 Sep 15;58(9):1282. doi: 10.3390/medicina58091282.
Abstract
During an acute SARS-CoV-2 infection, a diagnosis of Aplastic Anaemia associated with Paroxysmal Nocturnal Haemoglobinuria (AA/PNH) was made in a 78-year-old woman who had presented to the emergency department with severe pancytopenia. It is possible that she had subclinical AA/PNH that was unmasked during the acute COVID-19 infection, but we can also suspect a direct role of the virus in the pathogenesis of the disease, or we can hypothesize that COVID-19 infection changed the phosphatidylinositol glycan class A (PIGA) gene pathway.
摘要
在急性 SARS-CoV-2 感染期间，一位 78 岁女性因严重全血细胞减少症而到急诊科就诊，诊断为伴有阵发性夜间血红蛋白尿症（AA/PNH）的再生障碍性贫血。她可能患有亚临床 AA/PNH，在急性 COVID-19 感染期间被揭示，但我们也可以怀疑病毒在疾病发病机制中起直接作用，或者我们可以假设 COVID-19 感染改变了磷脂酰肌醇聚糖 A （PIGA）基因途径。
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