Aguilar Jeff Justin, Dhillon Vikram, Balasubramanian Suresh
School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.
Hematol Rep. 2024 Jan 17;16(1):42-49. doi: 10.3390/hematolrep16010005.
We report two cases of pancytopenia in patients after recovering from a mild COVID-19, now presenting as paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia. These cases illustrate a common pathway whereby a viral trigger causes the clonal expansion of a hematological disorder. Although the association of both cases with COVID-19 is temporal and COVID-19 may be an incidental diagnosis, the growing evidence related to the hematological effects of SARS-CoV-2 infection highlights the need for further investigation into the hematological consequences of COVID-19, particularly in the post-pandemic era.
我们报告了两例轻症新冠病毒病（COVID-19）康复后出现全血细胞减少的病例，目前表现为阵发性夜间血红蛋白尿（PNH）和再生障碍性贫血。这些病例说明了一种常见途径，即病毒触发导致血液系统疾病的克隆性扩增。尽管这两例病例与COVID-19的关联只是时间上的，且COVID-19可能是偶然诊断，但与严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染的血液学影响相关的证据越来越多，这凸显了进一步研究COVID-19血液学后果的必要性，尤其是在大流行后时代。
