Siddiqui Ruqaiyyah, Mungroo Mohammad Ridwane, Alharbi Ahmad M, Alfahemi Hasan, Khan Naveed Ahmed
College of Arts and Sciences, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.
Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah P.O. Box 27272, United Arab Emirates.
Microorganisms. 2022 Sep 19;10(9):1869. doi: 10.3390/microorganisms10091869.
Gut microbial composition codevelops with the host from birth and is influenced by several factors, including drug use, radiation, psychological stress, dietary changes and physical stress. Importantly, gut microbial dysbiosis has been clearly associated with several diseases, including cancer, rheumatoid arthritis and -associated diarrhoea, and is known to affect human health and performance. Herein, we discuss that a shift in the gut microbiota with age and reversal of age-related modulation of the gut microbiota could be a major contributor to the incidence of numerous age-related diseases or overall human performance. In addition, it is suggested that the gut microbiome of long-lived animals such as reptiles should be investigated for their unique properties and contribution to the potent defense system of these species could be extrapolated for the benefit of human health. A range of techniques can be used to modulate the gut microbiota to have higher abundance of "beneficial" microbes that have been linked with health and longevity.
肠道微生物组成从出生起就与宿主共同发育，并受到多种因素的影响，包括药物使用、辐射、心理压力、饮食变化和身体压力。重要的是，肠道微生物失调已与多种疾病明确相关，包括癌症、类风湿性关节炎和相关性腹泻，并且已知会影响人类健康和表现。在此，我们讨论肠道微生物群随年龄的变化以及与年龄相关的肠道微生物群调节的逆转可能是许多与年龄相关疾病的发病率或人类整体表现的主要促成因素。此外，有人建议应研究诸如爬行动物等长寿动物的肠道微生物组，以了解它们的独特特性，并且这些物种强大防御系统的贡献可能会被推断用于人类健康的益处。一系列技术可用于调节肠道微生物群，以使其具有更高丰度的与健康和长寿相关的“有益”微生物。
