Izumi H
Nihon Naibunpi Gakkai Zasshi. 1978 Jul 20;54(7):876-90. doi: 10.1507/endocrine1927.54.7_876.
It has been considered that hyperinsulinemia is one of the important factors in the development of obesity. With the purpose of investigating the mechanisms of hyperinsulinemia in obese rats induced by hypothalamic lesions (HTL), the time-caused changes in body weight, blood glucose and plasma immunoreactive insulin (IRI) levels in addition to histological changes in the pancreatic islet were studied. The following results were obtained. 1. The development of obesity, a rise of plasma IRI level and an enlargement of pancreatic islets were found in HTL rats. The enlargement of pancreatic islets was directly proportional to body weight, index of obesity and plasma IRI level. 2. The B cells of the pancreatic islets of HTL rats revealed well-developed Golgi apparatus and rough endoplasmic reticulum, and numerous degranulated and pale secretory granules. 3. A number of mixed cells were shown in the periphery of the pancreatic islets of HTL rats. 4. Emiocytotic phenomena of the granular discharge were encountered frequently in the B cells of the pancreatic islets of HTL rats. These histological findings of the B cells in HTL rats well reflected hypersecretion of insulin in this type of obesity.
人们认为高胰岛素血症是肥胖发生发展的重要因素之一。为了研究下丘脑损伤（HTL）诱导的肥胖大鼠高胰岛素血症的机制，研究了体重、血糖和血浆免疫反应性胰岛素（IRI）水平随时间的变化以及胰岛的组织学变化。获得了以下结果。1. 在HTL大鼠中发现了肥胖的发展、血浆IRI水平的升高和胰岛的增大。胰岛的增大与体重、肥胖指数和血浆IRI水平成正比。2. HTL大鼠胰岛的B细胞显示高尔基体和粗面内质网发达，有许多脱颗粒和浅色分泌颗粒。3. HTL大鼠胰岛周围出现了许多混合细胞。4. 在HTL大鼠胰岛的B细胞中经常遇到颗粒释放的胞吐现象。HTL大鼠B细胞的这些组织学发现很好地反映了这种类型肥胖中胰岛素的高分泌。
