Catalytic Hydrogenation Research Center, Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Zhejiang Green Pesticide Collaborative Innovation Center, Zhejiang University of Technology, Hangzhou 310014, China.
Agrowin (Ningbo) Bioscience Co., Ltd., Ningbo 315100, China.
Molecules. 2022 Sep 10;27(18):5879. doi: 10.3390/molecules27185879.
To discover novel herbicidal compounds with favorable activity, a range of phenylpyridine-moiety-containing α-trifluorothioanisole derivatives were designed, synthesized, and identified via NMR and HRMS. Preliminary screening of greenhouse-based herbicidal activity revealed that compound 5a exhibited >85% inhibitory activity against broadleaf weeds Amaranthus retroflexus, Abutilon theophrasti, and Eclipta prostrate at 37.5 g a.i./hm2, which was slightly superior to that of fomesafen. The current study suggests that compound 5a could be further optimized as an herbicide candidate to control various broadleaf weeds.
为了发现具有良好活性的新型除草剂化合物，设计、合成了一系列含苯并吡啶基-α-三氟甲硫基苯醚衍生物，并通过 NMR 和 HRMS 进行了鉴定。温室除草活性初步筛选表明，化合物 5a 在 37.5 g a.i./hm2 下对反枝苋、苘麻和鳢肠等阔叶杂草的抑制活性超过 85%，略优于氟磺胺草醚。本研究表明，化合物 5a 可进一步优化为候选除草剂，以防治各种阔叶杂草。
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