合成具有除草活性的含苯吡啶基部分的新型吡唑衍生物。
Synthesis of Novel Pyrazole Derivatives Containing Phenylpyridine Moieties with Herbicidal Activity.
机构信息
Catalytic Hydrogenation Research Center, Zhejiang Key Laboratory of Green Pesticides and Cleaner Production Technology, Zhejiang Green Pesticide Collaborative Innovation Center, Zhejiang University of Technology, Hangzhou 310014, China.
Agrowin (Ningbo) Bioscience Co., Ltd., Ningbo 315100, China.
出版信息
Molecules. 2022 Sep 23;27(19):6274. doi: 10.3390/molecules27196274.
To discover new compounds with favorable herbicidal activity, a range of phenylpyridine moiety-containing pyrazole derivatives were designed, synthesized, and identified via NMR and HRMS. Their herbicidal activities against six species of weeds were evaluated in a greenhouse via both pre- and post-emergence treatments at 150 g a.i./hm. The bioassay revealed that a few compounds exhibited moderate herbicidal activities against , , and in post-emergence treatment. For instance, compounds and demonstrated 50% inhibition activity against , which was slightly superior to pyroxasulfone. Thus, compounds and may serve as the new possible leading compounds for the discovery of post-emergence herbicides.
为了发现具有良好除草活性的新化合物，设计、合成了一系列含苯并吡啶基吡唑衍生物，并通过 NMR 和 HRMS 进行了鉴定。通过在温室中进行前处理和后处理，以 150 g a.i./hm 的用量，评估了它们对六种杂草的除草活性。生物测定结果表明，一些化合物在后处理中对 、 、 具有中等除草活性。例如，化合物 和 对 表现出 50%的抑制活性，略优于吡唑磺隆。因此，化合物 和 可能成为发现后处理除草剂的新的潜在先导化合物。
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