Eastern Health Clinical School, Monash University, Melbourne 3128, Australia.
Central Clinical School, Monash University, Melbourne 3004, Australia.
Nutrients. 2022 Sep 19;14(18):3875. doi: 10.3390/nu14183875.
Non-alcoholic fatty liver disease (NAFLD) has become the most prevalent liver disease in Australia and is recognised to play a role in the development of hepatocellular carcinoma (HCC). There are no clear guidelines regarding screening for HCC in NAFLD. The aim of this retrospective study was to compare the characteristics and survival rates of NAFLD-HCC to patients with non-NAFLD-HCC to help guide future research in this area.
A total of 152 HCC patients with either NAFLD ( = 36) or non-NAFLD ( = 116) were retrospectively analysed from the HCC database and medical records. Chi-square and independent t-test were used to compare baseline characteristics and Kaplan-Meier curves and Cox models were used for survival analysis.
Patients with NAFLD-HCC were more likely to be diagnosed due to symptoms rather than through screening, and at an older age, compared with non-NAFLD HCC. The median survival rates were lower in NAFLD-HCC (17.2 months) than in those with non-NAFLD-HCC (23.5 months).
There is a rise in the number of HCC cases in patients with NAFLD, and this has significant implications for hepatologists as they are presented with more advanced diseases and have poorer outcomes. Future studies on HCC will need to identify this group earlier in order to have an impact on the HCC survival rate.
非酒精性脂肪性肝病（NAFLD）已成为澳大利亚最常见的肝脏疾病，并被认为在肝细胞癌（HCC）的发展中起作用。目前尚无关于 NAFLD 患者 HCC 筛查的明确指南。本回顾性研究旨在比较 NAFLD-HCC 与非 NAFLD-HCC 患者的特征和生存率，以帮助指导该领域的未来研究。
从 HCC 数据库和病历中回顾性分析了 152 例 HCC 患者，其中有 NAFLD（n=36）或非 NAFLD（n=116）。使用卡方检验和独立 t 检验比较基线特征，使用 Kaplan-Meier 曲线和 Cox 模型进行生存分析。
与非 NAFLD-HCC 患者相比，NAFLD-HCC 患者更有可能因症状而不是通过筛查被诊断出来，并且年龄更大。NAFLD-HCC 患者的中位生存率（17.2 个月）低于非 NAFLD-HCC 患者（23.5 个月）。
NAFLD 患者的 HCC 病例数量有所增加，这对肝病专家具有重要意义，因为他们面临着更晚期的疾病，并且预后更差。未来的 HCC 研究需要更早地识别这一人群，以影响 HCC 的生存率。
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