Bioactive Compounds in : Mechanisms of Action, Focus on Their Anti-Inflammatory Properties.

作者信息

Chiș Adina, Noubissi Paul Aimé, Pop Oana-Lelia, Mureșan Carmen Ioana, Fokam Tagne Michel Archange, Kamgang René, Fodor Adriana, Sitar-Tăut Adela-Viviana, Cozma Angela, Orășan Olga Hilda, Hegheș Simona Codruța, Vulturar Romana, Suharoschi Ramona

机构信息

Department of Molecular Sciences, "Iuliu Hațieganu" University of Medicine and Pharmacy, 6 Louis Pasteur St, 400349 Cluj-Napoca, Romania.

Department of Animal Biology and Conservation, Faculty of Science, University of Buea, Buea P.O. Box 63, Cameroon.

出版信息

Plants (Basel). 2023 Dec 20;13(1):20. doi: 10.3390/plants13010020.

Abstract

() is a tropical tree native to Pakistan, India, Bangladesh, and Afghanistan; it is cultivated for its nutritious leaves, pods, and seeds. This scientific study was conducted to outline the anti-inflammatory properties and mechanisms of action of bioactive compounds from The existing research has found that the plant is used in traditional medicine due to its bioactive compounds, including phytochemicals: flavonoids and polyphenols. The compounds are thought to exert their anti-inflammatory effects due to: (1) inhibition of pro-inflammatory enzymes: quercetin and kaempferol inhibit the pro-inflammatory enzymes (cyclooxygenase and lipoxygenase); (2) regulation of cytokine production: isothiocyanates modulate signaling pathways involved in inflammation, such as the nuclear factor-kappa B (NF-kappa B) pathway; isothiocyanates inhibit the production of pro-inflammatory cytokines such as TNF-α (tumor necrosis factor α) and IL-1β (interleukin-1β); and (3) antioxidant activity: contains flavonoids, polyphenols, known to reduce oxidative stress and inflammation. The review includes 's effects on cardiovascular protection, anti-hypertensive activities, type 2 diabetes, inflammatory bowel disease, and non-alcoholic fatty liver disease (NAFLD). This research could prove valuable for exploring the pharmacological potential of and contributing to the prospects of developing effective medicines for the benefit of human health.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6806/10780634/8583dd92b3d4/plants-13-00020-g001.jpg

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