Hylton P D, Reichman O H
Neurosurgery. 1987 Jul;21(1):27-32. doi: 10.1227/00006123-198707000-00006.
Eight cases are presented to summarize our experience with patients initially evaluated for the new onset of either seizure activity or focal transient neurological deficits. Each was found to have a normal computed tomographic (CT) scan with and without iodinated contrast infusion. All subsequently returned with a CT scan indicative of a glioma 2 weeks to 39 months later. The apparent reasons for the difficulty in early diagnosis of glioma in certain instances are discussed. A review of the literature with an analysis of the conglomerate data is presented. These cases probably represent a subset of gliomas undergoing anaplastic dedifferentiation from relatively benign to more malignant forms. Recommendations for clinical and radiographic follow-up are outlined.
本文报告8例患者，以总结我们对最初因癫痫发作或局灶性短暂神经功能缺损新发症状而接受评估的患者的经验。所有患者在注入和未注入碘化造影剂的情况下计算机断层扫描（CT）均显示正常。随后，所有患者在2周-39个月后复查CT时均显示为胶质瘤。文中讨论了某些情况下胶质瘤早期诊断困难的明显原因。并对文献进行综述并分析汇总数据。这些病例可能代表了胶质瘤从相对良性向更恶性形式间变去分化的一个子集。文中概述了临床和影像学随访的建议。
