Department of Zoology, King Abdullah Campus, University of Azad Jammu and Kashmir, Muzaffarabad 13100, Pakistan.
Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran 61441, Saudi Arabia.
Viruses. 2022 Aug 31;14(9):1936. doi: 10.3390/v14091936.
Very few studies have been reported on hepatitis B in the State of Azad Jammu and Kashmir, Pakistan, and none of them are specific to the prevalence and causes of hepatitis B spread among educational institutes. This study aimed to estimate the prevalence of hepatitis B infection and its associated risk factors among the University of AJ and K population. An observational, cross-sectional, and analytical study was conducted with 7015 students and employees. Hepatitis B was detected by rapid immunochromatographic tests (ICTs), enzyme-linked immunosorbent assay (ELISA), and real-time quantitative PCR. A questionnaire and interview method was used to assess the disease knowledge and associated risk factors with hepatitis B through Chi-square, Fisher's exact test, and paired -test. Of the participants, 150 (2.13%) were found positive for the hepatitis B surface antigen (57.3% male and 42.7% female). Only 0.3% participants were found fully vaccinated against the hepatitis B virus. Among ethnic groups, the Syed tribe was found more prevalent for hepatitis B infection (40.6%), while use of contaminated mourning blades (95% CI: = 0.0001) was found as an overlooked risk factor. Hepatitis preventive awareness sessions were found to be very significant ( = 0.0001). The study showed that an overlooked risk factor is playing a key role in the spread of HBV in a tribe living worldwide, which must be addressed globally to eradicate hepatitis B. In Pakistan, a country-wide annual HBV vaccination program should be launched to control hepatitis B.
在巴基斯坦的自由查谟和克什米尔邦,几乎没有关于乙型肝炎的研究报告,而且没有一项研究专门针对教育机构中乙型肝炎传播的流行率和原因。本研究旨在估计 AJ 和 K 大学人群中乙型肝炎感染的流行率及其相关危险因素。 采用观察性、横断面和分析性研究方法,对 7015 名学生和员工进行了研究。通过快速免疫层析试验(ICT)、酶联免疫吸附试验(ELISA)和实时定量 PCR 检测乙型肝炎。采用问卷调查和访谈方法,通过卡方检验、Fisher 确切检验和配对检验评估疾病知识和与乙型肝炎相关的危险因素。 在参与者中,有 150 人(2.13%)乙型肝炎表面抗原阳性(57.3%为男性,42.7%为女性)。只有 0.3%的参与者完全接种了乙型肝炎病毒疫苗。在族裔群体中,赛义德部落的乙型肝炎感染更为普遍(40.6%),而使用受污染的哀悼刀片(95%CI:=0.0001)被认为是一个被忽视的危险因素。预防乙型肝炎的意识提高被认为是非常重要的(=0.0001)。 研究表明,一个被忽视的危险因素在全世界范围内一个部落的乙型肝炎病毒传播中起着关键作用,必须在全球范围内加以解决,以消除乙型肝炎。在巴基斯坦,应启动全国性的乙型肝炎疫苗接种计划来控制乙型肝炎。