爪哇猩猩（Hylobates moloch）的全基因组序列和组装。

Whole-genome sequence and assembly of the Javan gibbon (Hylobates moloch).

机构信息

Department of Biomolecular Engineering, University of California-Santa Cruz, Santa Cruz, CA 95064, USA.

Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, OR 97239, USA.

出版信息

J Hered. 2023 Mar 16;114(1):35-43. doi: 10.1093/jhered/esac043.

DOI:10.1093/jhered/esac043

PMID:36146896

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10019027/

Abstract

The Javan gibbon, Hylobates moloch, is an endangered gibbon species restricted to the forest remnants of western and central Java, Indonesia, and one of the rarest of the Hylobatidae family. Hylobatids consist of 4 genera (Holoock, Hylobates, Symphalangus, and Nomascus) that are characterized by different numbers of chromosomes, ranging from 38 to 52. The underlying cause of this karyotype plasticity is not entirely understood, at least in part, due to the limited availability of genomic data. Here we present the first scaffold-level assembly for H. moloch using a combination of whole-genome Illumina short reads, 10X Chromium linked reads, PacBio, and Oxford Nanopore long reads and proximity-ligation data. This Hylobates genome represents a valuable new resource for comparative genomics studies in primates.

摘要

爪哇猩猩，又称西里伯猩猩，是一种濒危的猩猩物种，仅分布于印度尼西亚爪哇岛西部和中部的森林残余地，也是长臂猿科中最稀有的物种之一。长臂猿科由 4 个属（合趾猿属、猩猩属、毛冠长臂猿属和白掌长臂猿属）组成，其染色体数量不同，范围从 38 到 52 条。这种染色体组型可塑性的根本原因尚不完全清楚，至少部分原因是由于基因组数据的有限可用性。在这里，我们使用全基因组 Illumina 短读、10X Chromium 连接读、PacBio 和 Oxford Nanopore 长读以及邻近连接数据，为 H. moloch 提供了第一个支架水平的组装。这个 Hylobates 基因组是灵长类动物比较基因组学研究的宝贵新资源。