Department of General Medicine, Government Medical College and Hospital, Chandigarh, India.
Department of Pathology, Government Medical College and Hospital, Chandigarh, India.
J R Coll Physicians Edinb. 2022 Jun;52(2):105-109. doi: 10.1177/14782715221107948. Epub 2022 Jun 29.
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with vascular complications that are attributable to dysregulated platelet reactivity as measured by mean platelet volume (MPV). This study aimed at determining a relationship between MPV and glycaemic control in new-onset T2DM.
This was a prospective study conducted on 236 new-onset T2DM patients divided in two groups as group A, glycosylated haemoglobin A1c (HbA1c < 7.9%; = 70) and group B, HbA1c ⩾ 8% ( = 107) who were followed up for 6 months for change in platelet and glycaemic parameters.
At 6-month follow-up, there was a significant decrease in HbA1c and MPV (group A (HbA1c: 7.40 ± 0.40 vs 7.03 ± 0.23%, < 0.03; MPV: 9.65 fl ± 0.74 vs 9.46 fl ± 0.71, < 0.001) and group B (HbA1c: 10.59 ± 1.89% vs 9.29 ± 1.50%, < 0.001; MPV: 10.89 fL ± 1.29 vs. 10.23 fL ± 1.40, p< 0.001)). The percentage decline in HbA1c was more in group B (11.81 ± 5.87 vs 4.76 ± 4.58, < 0.01). There was a positive correlation between ΔMPV and ΔHbA1c in group B; however, we did not observe significant correlation for group A.
We interpret that in people with diabetes with baseline HbA1c ⩾ 8%, with improvement in glycaemic control, there is a significant decrease in MPV. We propose that a routine MPV testing can be used as a potential marker for glycaemic control in T2DM.
2 型糖尿病（T2DM）是一种代谢紊乱疾病，与血管并发症有关，这些并发症可归因于血小板反应性的失调，这可以通过平均血小板体积（MPV）来衡量。本研究旨在确定新诊断的 T2DM 患者中 MPV 与血糖控制之间的关系。
这是一项前瞻性研究，共纳入 236 例新诊断的 T2DM 患者，根据糖化血红蛋白（HbA1c）水平分为两组：A 组，HbA1c < 7.9%（n = 70）；B 组，HbA1c ⩾ 8%（n = 107）。两组患者均随访 6 个月，观察血小板和血糖参数的变化。
在 6 个月的随访中，A 组（HbA1c：7.40 ± 0.40 比 7.03 ± 0.23%， < 0.03；MPV：9.65 fl ± 0.74 比 9.46 fl ± 0.71， < 0.001）和 B 组（HbA1c：10.59 ± 1.89%比 9.29 ± 1.50%， < 0.001；MPV：10.89 fL ± 1.29 比 10.23 fL ± 1.40， < 0.001）的 HbA1c 显著降低，MPV 也显著降低。B 组 HbA1c 的下降百分比更大（11.81 ± 5.87%比 4.76 ± 4.58%， < 0.01）。B 组中 ΔMPV 与 ΔHbA1c 呈正相关；然而，我们没有观察到 A 组有显著相关性。
我们的解释是，在基线 HbA1c ⩾ 8%的糖尿病患者中，随着血糖控制的改善，MPV 显著降低。我们提出，常规检测 MPV 可作为 T2DM 血糖控制的潜在标志物。
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