Association of Mean Platelet Volume Expression with Bone Mineral Density in Patients with T2DM and CKD.

OBJECTIVE

To investigate the clinical significance of mean platelet volume (MPV) in patients with type 2 diabetes mellitus (T2DM) complicated with chronic kidney disease (CKD), and its association with bone mineral density (BMD).

METHODS

A retrospective analysis was conducted on 296 T2DM patients with CKD. Based on MPV values, patients were divided into Group A (n=177, MPV 7.50-11.00 fL) and Group B (n=119, MPV >11.00 fL). Clinical and biochemical parameters including BMD were compared between groups. Pearson correlation and multiple linear regression were used to evaluate the relationship between MPV and BMD.

RESULTS

Group A showed significantly higher levels of PLT, SUA, and L1-L4 BMD than Group B (P<0.05); no statistically significant differences were found in other indicators between the groups (P>0.05). Pearson correlation analysis showed that MPV was negatively correlated with PLT (r=-0.253, P=0.012), SUA (r=-0.246, P=0.015), L1-L4 BMD (r=-0.351, P<0.01), femoral BMD (r=-0.271, P=0.007), and Ward BMD (r=-0.238, P=0.019). Multiple linear regression analysis revealed that high MPV was independently associated with lower L1-L4 BMD (β=-0.066, P=0.003).

CONCLUSION

High MPV is closely related to BMD in T2DM patients with CKD, especially L1-L4 BMD, and may serve as a potential indicator for the occurrence of osteoporosis.