Qiu Fangxin, Yin Yulei, Zhang Ning, Yao Dandan
Department of Nephrology, People's Hospital of Chengyang District, Qingdao City, Shandong, 266109, People's Republic of China.
Department of Endocrinology, People's Hospital of Chengyang District, Qingdao City, Shandong, 266109, People's Republic of China.
Int J Gen Med. 2025 Aug 5;18:4239-4249. doi: 10.2147/IJGM.S535847. eCollection 2025.
To investigate the clinical significance of mean platelet volume (MPV) in patients with type 2 diabetes mellitus (T2DM) complicated with chronic kidney disease (CKD), and its association with bone mineral density (BMD).
A retrospective analysis was conducted on 296 T2DM patients with CKD. Based on MPV values, patients were divided into Group A (n=177, MPV 7.50-11.00 fL) and Group B (n=119, MPV >11.00 fL). Clinical and biochemical parameters including BMD were compared between groups. Pearson correlation and multiple linear regression were used to evaluate the relationship between MPV and BMD.
Group A showed significantly higher levels of PLT, SUA, and L1-L4 BMD than Group B (P<0.05); no statistically significant differences were found in other indicators between the groups (P>0.05). Pearson correlation analysis showed that MPV was negatively correlated with PLT (r=-0.253, P=0.012), SUA (r=-0.246, P=0.015), L1-L4 BMD (r=-0.351, P<0.01), femoral BMD (r=-0.271, P=0.007), and Ward BMD (r=-0.238, P=0.019). Multiple linear regression analysis revealed that high MPV was independently associated with lower L1-L4 BMD (β=-0.066, P=0.003).
High MPV is closely related to BMD in T2DM patients with CKD, especially L1-L4 BMD, and may serve as a potential indicator for the occurrence of osteoporosis.
探讨平均血小板体积（MPV）在2型糖尿病（T2DM）合并慢性肾脏病（CKD）患者中的临床意义及其与骨密度（BMD）的关系。
对296例T2DM合并CKD患者进行回顾性分析。根据MPV值，将患者分为A组（n = 177，MPV 7.50 - 11.00 fL）和B组（n = 119，MPV > 11.00 fL）。比较两组间包括BMD在内的临床和生化参数。采用Pearson相关性分析和多元线性回归评估MPV与BMD的关系。
A组的血小板计数（PLT）、血尿酸（SUA）和L1 - L4椎体骨密度水平显著高于B组（P < 0.05）；两组间其他指标差异无统计学意义（P > 0.05）。Pearson相关性分析显示，MPV与PLT（r = -0.253，P = 0.012）、SUA（r = -0.246，P = 0.015）、L1 - L4椎体骨密度（r = -0.351，P < 0.01）、股骨骨密度（r = -0.271，P = 0.007）和Ward三角区骨密度（r = -0.238，P = 0.019）呈负相关。多元线性回归分析显示，高MPV独立与较低的L1 - L4椎体骨密度相关（β = -0.066，P = 0.003）。
高MPV与T2DM合并CKD患者的骨密度密切相关，尤其是L1 - L4椎体骨密度，可能是骨质疏松发生的潜在指标。
