BCL2和CK20表达在预测膀胱癌行为模式中的价值：一项横断面研究
The value of BCL2 and CK20 expression in predicting behavioral patterns of bladder cancer, a cross sectional study.
作者信息
Pourebrahimi Elham, Moradi Tabriz Hedieh, Miratashi Yazdi Seyed Amir, Nazar Elham, Batmani Sara
机构信息
Department of Pathology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Ann Med Surg (Lond). 2022 Aug 23;81:104372. doi: 10.1016/j.amsu.2022.104372. eCollection 2022 Sep.
BACKGROUND
Several biomarkers have been investigated to predict the biological behavior and prognosis of patients with bladder cancer. We evaluated the role of two important markers including BCL2 and CK20 in evaluating the biological behavior of bladder tumors.
METHODS
This cross-sectional study was performed on 30 patients suffering from one of the neoplasms of the bladder. To evaluate the expression of BCL2 and CK20 markers, the neoplastic tissue sample was initially extracted and immunohistochemistry staining was employed.
RESULTS
The positivity of CK20 and BCL2 in the patients' specimens was found to be 53.3% and 10.0%, respectively. There was no association between CK20 and BCL2 expressions and tumor size, tumor stage, or tumor-related vascular invasion, but BCL2 expression was shown to be higher in the low-grade specimens, while the expression rate of CK20 was found to be significantly higher in high grade samples.
CONCLUSION
Evaluation of the expression of CK20 and BCL2 markers can be very valuable in predicting bladder tumor grade.
背景
已经对几种生物标志物进行了研究，以预测膀胱癌患者的生物学行为和预后。我们评估了包括BCL2和CK20在内的两种重要标志物在评估膀胱肿瘤生物学行为中的作用。
方法
对30例患有膀胱肿瘤之一的患者进行了这项横断面研究。为了评估BCL2和CK20标志物的表达，首先提取肿瘤组织样本并采用免疫组织化学染色。
结果
发现患者标本中CK20和BCL2的阳性率分别为53.3%和10.0%。CK20和BCL2的表达与肿瘤大小、肿瘤分期或肿瘤相关血管侵犯之间没有关联，但BCL2在低级别标本中的表达较高，而CK20的表达率在高级别样本中显著更高。
结论
评估CK20和BCL2标志物的表达在预测膀胱肿瘤分级方面可能非常有价值。
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