Irajpour Matin, Noorshargh Pegah, Peyman Alireza
Isfahan Eye Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
J Curr Ophthalmol. 2022 Jul 26;34(2):229-233. doi: 10.4103/joco.joco_16_22. eCollection 2022 Apr-Jun.
To evaluate the long-term outcome of corneal cross-linking (CXL) for pellucid marginal degeneration (PMD).
In a retrospective study, forty eyes of forty patients were enrolled. All subjects had undergone CXL for PMD at least 5 years before the assessments. Visual acuity, refraction, and topography data were compared to their respective values before CXL.
The comparison between mean preoperative logMAR uncorrected visual acuity and 5-year postoperative evaluation revealed no significant change (1.20 ± 0.65 and 1.17 ± 0.64, > 0.05). No statistically significant difference was noted comparing preoperative mean logMAR best-corrected visual acuity (BCVA) and postoperative mean logMAR BCVA (0.24 ± 0.19 and 0.22 ± 0.20, > 0.05). We did not find any significant difference between pre- and postoperative spherical equivalent and spherical refractive errors ( = 0.419 and = 0.396, respectively). Regarding the BCVA Snellen lines, 23 eyes had no significant change in pre- and postoperative examinations, 11 eyes had improvement, and 6 subjects showed worsening defined as significant when two or more lines change. The spherical equivalent refractive error improved in 4 subjects, was stable in 25, and worsened in 11 subjects, while a 0.5 diopter or more myopic change was considered significant. Furthermore, regarding steep keratometry values, 25 subjects were stable, 7 had improvements, and 8 worsened.
CXL appears to be a safe and effective procedure to halt the progression of PMD.
评估角膜交联术（CXL）治疗透明边缘变性（PMD）的长期疗效。
在一项回顾性研究中，纳入了40例患者的40只眼。所有受试者在评估前至少5年接受了CXL治疗PMD。将视力、验光和地形图数据与其在CXL术前的各自值进行比较。
术前平均logMAR未矫正视力与术后5年评估结果的比较显示无显著变化（分别为1.20±0.65和1.17±0.64，P>0.05）。术前平均logMAR最佳矫正视力（BCVA）与术后平均logMAR BCVA比较，未发现统计学上的显著差异（分别为0.24±0.19和0.22±0.20，P>0.05）。我们未发现术前和术后等效球镜度及球镜屈光不正之间有任何显著差异（分别为P=0.419和P=0.396）。关于BCVA Snellen视力表行数，23只眼在术前和术后检查中无显著变化，11只眼有改善，6只眼视力下降，当两行或更多行变化时被定义为显著下降。等效球镜屈光不正4例改善，25例稳定，11例恶化，而近视变化0.5屈光度或更多被认为是显著的。此外，关于陡峭角膜曲率值，25例稳定，7例改善，8例恶化。
CXL似乎是一种安全有效的阻止PMD进展的手术。
