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miRNA 生物标志物在预测肺腺癌总生存结局中的应用。

Application of miRNA Biomarkers in Predicting Overall Survival Outcomes for Lung Adenocarcinoma.

机构信息

Department of Pharmacy, Xi'an Chest Hospital, Xi'an, Shaanxi, China.

Northwestern Polytechnical University, Xi'an, Shaanxi, China.

出版信息

Biomed Res Int. 2022 Sep 12;2022:5249576. doi: 10.1155/2022/5249576. eCollection 2022.

DOI:10.1155/2022/5249576
PMID:36147635
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9485713/
Abstract

BACKGROUND

With the development of research, the importance of microRNAs (miRNAs) in the occurrence, metastasis, and prognosis of lung adenocarcinoma (LUAD) has attracted extensive attention. This study is aimed at predicting overall survival (OS) results through bioinformatics to identify novel miRNA biomarkers and hub genes.

MATERIALS AND METHODS

The data of LUAD-related miRNA and mRNA samples was downloaded from The Cancer Genome Atlas (TCGA) database. Upon screening and pretreatment of initial data, TCGA data were analyzed using R platform and a series of analytical tools to identify biomarkers with high specificity and sensitivity.

RESULTS

7 miRNAs and 13 hub genes that had strong relation to the overall surviving status were identified in patients with LUAD. The expression of seven miRNAs (hsa-miR-19a-3p, hsa-miR-126-5p, hsa-miR-556-3p, hsa-miR-671-5p, hsa-miR-937-3p, hsa-miR-4664-3p, and hsa-miR-4746-5p) could apparently improve the OS rate of patient with LUAD. The 13 hub genes, namely, , , , , , , , , , , , , and , showed a correlation with the OS status.

CONCLUSION

7 miRNAs were identified as novel biomarkers for the prognosis of patients with LUAD. This study offered a deeper comprehension of LUAD treatment and prognosis from the molecular level and helped enhance the understanding of the pathogenesis and potential molecular events of LUAD.

摘要

背景

随着研究的发展，微小 RNA（miRNA）在肺腺癌（LUAD）发生、转移和预后中的重要性引起了广泛关注。本研究旨在通过生物信息学预测总生存期（OS）结果，以鉴定新的 miRNA 生物标志物和枢纽基因。

材料和方法

从癌症基因组图谱（TCGA）数据库下载 LUAD 相关 miRNA 和 mRNA 样本数据。对初始数据进行筛选和预处理后，使用 R 平台和一系列分析工具对 TCGA 数据进行分析，以鉴定具有高特异性和敏感性的生物标志物。

结果

鉴定出 7 个与 LUAD 总生存状态密切相关的 miRNA 和 13 个枢纽基因。在 LUAD 患者中，七种 miRNA（hsa-miR-19a-3p、hsa-miR-126-5p、hsa-miR-556-3p、hsa-miR-671-5p、hsa-miR-937-3p、hsa-miR-4664-3p 和 hsa-miR-4746-5p）的表达明显提高了 LUAD 患者的 OS 率。这 13 个枢纽基因，即、、、、、、、、、、、和，与 OS 状态相关。

结论

鉴定出 7 个 miRNA 是 LUAD 患者预后的新型生物标志物。本研究从分子水平上对 LUAD 的治疗和预后有了更深入的了解，有助于增强对 LUAD 发病机制和潜在分子事件的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/ed6c6c32c8d7/BMRI2022-5249576.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/d127ed15eed7/BMRI2022-5249576.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e5bf68801191/BMRI2022-5249576.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/3c0f5781034b/BMRI2022-5249576.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e253904ad0b4/BMRI2022-5249576.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e44cc692753d/BMRI2022-5249576.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/fbf04465acf4/BMRI2022-5249576.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/01a734cdf548/BMRI2022-5249576.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e32efdb08d9c/BMRI2022-5249576.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/ed6c6c32c8d7/BMRI2022-5249576.009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/d127ed15eed7/BMRI2022-5249576.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e5bf68801191/BMRI2022-5249576.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/3c0f5781034b/BMRI2022-5249576.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e253904ad0b4/BMRI2022-5249576.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e44cc692753d/BMRI2022-5249576.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/fbf04465acf4/BMRI2022-5249576.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/01a734cdf548/BMRI2022-5249576.007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/e32efdb08d9c/BMRI2022-5249576.008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5244/9485713/ed6c6c32c8d7/BMRI2022-5249576.009.jpg

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