Rijndam Rehabilitation, Rotterdam, The Netherlands.
Department of Rehabilitation Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Disabil Rehabil. 2023 Oct;45(20):3323-3329. doi: 10.1080/09638288.2022.2125084. Epub 2022 Sep 22.
To evaluate physical fitness and its association with fatigue in patients with low grade glioma (LGG).
Cross-sectional study. Muscle strength was measured with a digital dynamometer, cardiorespiratory fitness (peak oxygen uptake (VO2peak), maximal workload (MWL)) by cardiopulmonary-exercise-testing, and fatigue by using the Multidimensional Fatigue Inventory.
Thirty patients were included, mean age of 44.1 (SD11.2) years, and 67% were men, 31.2 (SD18) months post-diagnosis. Muscle strength ( < 0.01), and cardiorespiratory fitness (VO MWL) ( < 0.01) were significantly decreased compared to predicted values based on age and gender. Thirty percent of the patients experienced severe physical fatigue, and severe mental fatigue was reported in 57% of the patients. Cardiorespiratory fitness showed weak to moderate (r - 0.46 to r - 0.52) but significant ( < 0.01) correlations with physical fatigue, not with mental and general fatigue. Muscle strength was not associated with fatigue. A lower VO was independently associated with a higher level of physical fatigue, adjusted for Karnofsky Performance Status (R 0.40).
Physical fitness (muscle strength, cardiorespiratory fitness) is reduced in patients with LLG, and a lower level of cardiorespiratory fitness (VO) is independently associated with a higher level of experienced physical fatigue. Trials to explore the benefit of exercise programs to improve cardiorespiratory fitness and, consequently, fatigue are warranted.Implications for rehabilitationPhysical fitness (muscle strength and cardiorespiratory fitness) is reduced in patients with low-grade glioma.Patients with low-grade glioma should be screened for fatigue with the multidimensional fatigue inventory, to differentiate between mental and physical fatigue.Patients with low-grade glioma with severe physical fatigue should be screened for reduced physical fitness, especially cardiorespiratory fitness by objective cardiopulmonary-exercise-testing.Rehabilitation exercise programs to improve cardiorespiratory fitness and, consequently, (physical) fatigue could be warranted in patients with low-grade glioma.
评估低级别胶质瘤（LGG）患者的身体机能及其与疲劳的关系。
这是一项横断面研究。使用数字测力计测量肌肉力量，通过心肺运动试验测量心肺功能（峰值摄氧量（VO2peak）、最大工作负荷（MWL）），并使用多维疲劳量表评估疲劳。
共纳入 30 例患者，平均年龄 44.1（11.2）岁，其中 67%为男性，诊断后 31.2（18）个月。与基于年龄和性别预测值相比，肌肉力量（ < 0.01）和心肺功能（VO MWL）（ < 0.01）显著降低。30%的患者出现严重的体力疲劳，57%的患者报告出现严重的精神疲劳。心肺功能与体力疲劳呈弱至中度相关（r - 0.46 至 r - 0.52），但有统计学意义（ < 0.01），而与精神疲劳和一般疲劳无关。肌肉力量与疲劳无关。在校正卡诺夫斯基表现状态（R 0.40）后，较低的 VO 与更高水平的体力疲劳独立相关。
LGG 患者的身体机能（肌肉力量、心肺功能）降低，较低的心肺功能（VO）与较高水平的体力疲劳独立相关。有必要开展试验以探索运动方案改善心肺功能从而改善疲劳的益处。
低级别胶质瘤患者的身体机能（肌肉力量和心肺功能）降低。低级别胶质瘤患者应使用多维疲劳量表进行疲劳筛查，以区分精神疲劳和体力疲劳。有严重体力疲劳的低级别胶质瘤患者应筛查身体机能下降，特别是心肺功能，方法是通过客观心肺运动试验。在低级别胶质瘤患者中，有必要开展改善心肺功能、进而改善（体力）疲劳的康复运动方案。
