Hölter Sabine M, Wells Sara, Voikar Vootele
Helmholtz Zentrum München, Germany.
Mary Lyon Centre at MRC Harwell, Harwell Campus, UK.
Lab Anim. 2023 Feb;57(1):79-83. doi: 10.1177/00236772221117451. Epub 2022 Sep 23.
The key goal in biomedical research is a better understanding of disease aetiologies, which ideally results in strategies and recommendations for the prevention of diseases before they arise, and in the development of effective therapies. However, many concerns have been expressed about the reproducibility and the translational validity of preclinical research in animal models to inform clinical trials in humans. It has been proposed that improving internal, external and construct validity of animal studies will lead to improved translatability. Automated behaviour monitoring in the animal's home cage, which allows for longitudinal assessment of individual trajectories over sufficiently long intervals for (chronic) drug treatment or phenotype progression, is a promising solution to these problems.
生物医学研究的关键目标是更好地理解疾病病因，理想情况下，这会带来在疾病发生前预防疾病的策略和建议，以及有效疗法的开发。然而，人们对动物模型中的临床前研究的可重复性和转化有效性提出了诸多担忧，这些研究旨在为人类临床试验提供信息。有人提出，提高动物研究的内部、外部和结构效度将提高可转化性。在动物饲养笼中进行自动行为监测，能够在足够长的时间间隔内对个体轨迹进行纵向评估，以用于（长期）药物治疗或表型进展研究，这是解决这些问题的一个有前景的方法。
