Olivera Lopez Soledad Belen, Raices Micaela, Basbus Luis, Cerini Matias, Minatta Nicolas, Dietrich Agustin, Smith David
Hospital Italiano de Buenos Aires.
Rev Fac Cien Med Univ Nac Cordoba. 2022 Sep 16;79(3):217-222. doi: 10.31053/1853.0605.v79.n3.32403.
Between 5-10% of patients who undergo curative surgery for colorectal cancer (CRC) will present recurrence of their disease on the lungs. Surgical treatment of pulmonary metastases (PM) has gained popularity over the years, different publications report an overall survival rate at 5 years of between 30% and 60%. We present a review of patients with PM resections of CRC treated in a single center in Argentina.
A descriptive, observational, retrospective study was conducted between 2008 and 2018. All patients with pulmonary metastasectomy of colorectal cancer were included. The primary endpoint was to evaluate overall survival and disease-free survival. Possible prognostic factors were evaluated as a secondary endpoint.
A total of 99 surgeries were performed in the 68 patients, the resection was multiple in 48.5%, with more than 3 nodules in 13%. Overall and progression-free survival at 5 years was 55% and 27%, respectively. In the statistical analysis we found that the lesions in more than one lobe (p = 0.015) and the resection of more than 3 nodules (p = 0.011) presented a lower overall survival.
In this retrospective analysis we evidenced comparable values to the world literature regarding morbidity, mortality, overall survival and progression-free. In our series, patients with disease in more than one lobe or more than three resected lesions had significantly lower overall survival.
在接受结直肠癌（CRC）根治性手术的患者中，有5%至10%会出现肺部疾病复发。多年来，肺转移瘤（PM）的手术治疗越来越普遍，不同的出版物报道5年总生存率在30%至60%之间。我们对在阿根廷一个单一中心接受CRC肺转移瘤切除术的患者进行了综述。
在2008年至2018年期间进行了一项描述性、观察性、回顾性研究。纳入所有接受结直肠癌肺转移瘤切除术的患者。主要终点是评估总生存率和无病生存率。将可能的预后因素作为次要终点进行评估。
68例患者共进行了99次手术，48.5%的切除为多发，13%有超过3个结节。5年总生存率和无进展生存率分别为55%和27%。在统计分析中，我们发现累及一个以上肺叶的病变（p = 0.015）和切除超过3个结节（p = 0.011）的患者总生存率较低。
在这项回顾性分析中，我们证明在发病率、死亡率、总生存率和无进展生存率方面与世界文献中的数值相当。在我们的系列研究中，累及一个以上肺叶或切除超过三个病变的患者总生存率显著较低。
