慢性肾脏病的骨骼肌并发症。
Skeletal Muscle Complications in Chronic Kidney Disease.
机构信息
Department of Physical Therapy, School of Health and Human Sciences, Indiana University Purdue University, CF-326, 1140 W. Michigan St., Indianapolis, IN, 46202, USA.
Division of Nephrology & Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
出版信息
Curr Osteoporos Rep. 2022 Dec;20(6):410-421. doi: 10.1007/s11914-022-00751-w. Epub 2022 Sep 23.
PURPOSE OF REVIEW
To provide an overview of the recent literature investigating the pathophysiology of skeletal muscle changes, interventions for skeletal muscle, and effects of exercise in chronic kidney disease (CKD).
RECENT FINDINGS
There are multiple CKD-related changes that negatively impact muscle size and function. However, the variability in the assessment of muscle size, in particular, hinders the ability to truly understand the impact it may have in CKD. Exercise interventions to improve muscle size and function demonstrate inconsistent responses that warrant further investigation to optimize exercise prescription. Despite progress in the field, there are many gaps in the knowledge of the pathophysiology of sarcopenia of CKD. Identifying these gaps will help in the design of interventions that can be tested to target muscle loss and its consequences such as impaired mobility, falls, and poor quality of life in patients with CKD.
目的综述
探讨慢性肾脏病（CKD）中骨骼肌变化的病理生理学、骨骼肌干预措施以及运动的作用的最新文献。
最近的发现
CKD 会引起多种负性变化，影响肌肉大小和功能。然而，肌肉大小的评估存在很大差异，这尤其妨碍了人们真正了解其对 CKD 的影响。改善肌肉大小和功能的运动干预措施的反应不一致，需要进一步研究以优化运动处方。尽管该领域取得了进展，但 CKD 性肌少症的病理生理学知识仍存在许多空白。确定这些空白将有助于设计可以进行测试的干预措施，以针对肌肉减少及其后果（如 CKD 患者的活动能力下降、跌倒和生活质量下降）。
Zotero 插件