Kocher Laurence, Anton Fernand, Reeh Peter W, Handwerker Hermann O
II. Physiologisches Institut, Im Neuenheimer Feld 326, D-6900 HeidelbergF.R.G.
Pain. 1987 Jun;29(3):363-373. doi: 10.1016/0304-3959(87)90051-0.
Carrageenan was subcutaneously injected in the area innervated by the saphenous nerve. Part of the mechano-heat sensitive C-fiber receptors (CHM) located inside or at the border of the inflamed area showed an enhanced responsiveness to heat stimulation (sensitization). Those CMH units exhibited spontaneous activity; their mechanical thresholds (von Frey) were higher than those of not spontaneously active fibers. None of the units located outside of the inflamed area displayed sensitization. The data reveal that only part of the CMH units in a uniformly inflamed skin area shows signs of sensitization. Our results are compared to those obtained in other inflammatory processes. The relation to inflammatory pain and to hyperalgesia and the contribution of endogenous substances to sensitization of CMH units are discussed.
将角叉菜胶皮下注射到隐神经支配的区域。位于炎症区域内部或边界的部分机械热敏感C纤维受体（CHM）对热刺激表现出增强的反应性（致敏）。那些CMH单位表现出自发性活动；它们的机械阈值（von Frey）高于非自发性活动纤维。位于炎症区域之外的单位均未显示致敏现象。数据表明，在均匀炎症的皮肤区域中，只有部分CMH单位表现出致敏迹象。我们的结果与其他炎症过程中获得的结果进行了比较。讨论了与炎性疼痛、痛觉过敏的关系以及内源性物质对CMH单位致敏的作用。
