单侧和双侧去势及隐睾症对大鼠血清促性腺激素的影响。

Effect of unilateral and bilateral castration and cryptorchidism on serum gonadotrophins in the rat.

作者信息

Gomes W R, Jain S K

出版信息

J Endocrinol. 1976 Feb;68(02):191-6. doi: 10.1677/joe.0.0680191.

DOI:10.1677/joe.0.0680191

Abstract

The effects of unilateral and bilateral cryptorchidism and castration on serum concentrations of testosterone, FSH and LH in adult male rats were examined. The results provide no evidence for compensatory growth or development of the remaining scrotal testes up to 32 days after unilateral castration, although the scrotal testis of unilaterally cryptorchid rats showed enlargement when compared with those of control rats (P less than 0 - 05) at 32 days. Unilateral treatments had few significant effects on serum hormones, but testosterone was increased on day 4 (P less than 0 - 05) in unilaterally cryptorchid rats and on day 32 (P less than 0 - 05) in unilaterally castrated rats, compared with controls, and FSH levels were higher in unilaterally castrated rats on day 16 (P less than 0 - 05). Bilateral cryptorchidism caused an increase in serum FSH within 4 days (P less than 0 - 05) and in serum LH by 8 days (P less than 0-05) after surgery, with both hormones reaching levels double those found in control rats (P less than 0 - 01) by day 16, while testosterone levels were maintained at or above control values. Bilateral castration resulted in a marked decrease in testosterone levels (P less than 0 - 01) and a sharp increase in serum gonadotrophins. FSH had nearly doubled (P less than 0 - 01) and LH had increased fourfold (P less than 0 - 01) 4 days after castration, their levels reaching 773% (LH) and 287% (FSH) of control values by 32 days (P less than 0 - 01). The observations support the hypothesis of a separate, testosterone-independent feedback system of the testis on the hypophysis.

摘要

研究了单侧和双侧隐睾及去势对成年雄性大鼠血清睾酮、促卵泡激素（FSH）和促黄体生成素（LH）浓度的影响。结果表明，单侧去势后长达32天，未发现剩余阴囊内睾丸有代偿性生长或发育的证据，尽管单侧隐睾大鼠的阴囊内睾丸在32天时与对照大鼠相比出现了增大（P<0.05）。单侧处理对血清激素影响不大，但与对照相比，单侧隐睾大鼠在第4天睾酮水平升高（P<0.05），单侧去势大鼠在第32天睾酮水平升高（P<0.05），单侧去势大鼠在第16天FSH水平较高（P<0.05）。双侧隐睾术后4天血清FSH升高（P<0.05），8天血清LH升高（P<0.05），至第16天两种激素水平均达到对照大鼠的两倍（P<0.01），而睾酮水平维持在对照值或高于对照值。双侧去势导致睾酮水平显著下降（P<0.01），血清促性腺激素急剧升高。去势后4天，FSH几乎翻倍（P<0.01），LH增加了四倍（P<0.01），至32天时其水平分别达到对照值的7礂%（LH）和287%（FSH）（P<0.01）。这些观察结果支持睾丸对垂体存在一个独立于睾酮的反馈系统的假说。