National Clinical Research Center for Hematologic Diseases, Suzhou, 215006, China.
Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Front Med. 2022 Oct;16(5):815-826. doi: 10.1007/s11684-021-0891-0. Epub 2022 Sep 24.
Oral drugs such as ibrutinib play an important role in the treatment of mature B-cell lymphoma (BCL) due to their reliable efficacy, manageable safety, high accessibility, and convenience for use. Still, no guidelines or consensus focusing on oral drug therapies for BCL is available. To provide a reference of oral agent-based treatment for mature BCL, a panel of experts from the Lymphocyte Disease Group, Chinese Society of Hematology, Chinese Medical Association conducted an extensive discussion and reached a consensus on oral drugs for Chinese BCL patients on the basis of the current application status of oral drugs in China, combined with the latest authoritative guidelines in the world and current research reports. This consensus reviewed the application of oral drugs in the treatment of BCL and the latest research and provided appropriate recommendations on the use of oral drugs for indolent or aggressive BCL patients. With the deepening of research and the development of standardized clinical applications, oral medications will bring better treatment to BCL patients, enabling more patients to benefit from them.
口服药物,如伊布替尼,由于其可靠的疗效、可管理的安全性、高可及性和使用方便性,在成熟 B 细胞淋巴瘤(BCL)的治疗中发挥着重要作用。然而,目前尚无专门针对 BCL 口服药物治疗的指南或共识。为了为成熟 BCL 的口服药物治疗提供参考,中华医学会血液学分会淋巴细胞疾病学组的一组专家在结合中国目前口服药物的应用现状、结合世界最新权威指南和当前研究报告的基础上,就中国 BCL 患者的口服药物进行了广泛讨论并达成共识。本共识综述了口服药物在 BCL 治疗中的应用及最新研究进展,并就惰性或侵袭性 BCL 患者的口服药物使用提供了适当的建议。随着研究的深入和规范化临床应用的发展,口服药物将为 BCL 患者带来更好的治疗效果,使更多的患者从中受益。