University of Sarajevo, Institute for Genetic Engineering and Biotechnology, Zmaja od Bosne 8, 71000 Sarajevo, Bosnia and Herzegovina.
Institute for Medical Research and Occupational Health, Mutagenesis Unit, Ksaverska cesta 2, 10000 Zagreb, Croatia.
Mutat Res Genet Toxicol Environ Mutagen. 2022 Oct;882:503546. doi: 10.1016/j.mrgentox.2022.503546. Epub 2022 Sep 6.
Medical radiation exposures have been reduced significantly with modern equipment and protection measures. Biomonitoring of medical personnel can provide information concerning possible effects of radiation exposure. However, chromosome aberration (CA) analysis is now recommended only when the estimated effective dose is 200 mSv or higher. In this retrospective study in Bosnia and Herzegovina, we have measured the cytogenetic status of medical workers and healthy volunteers (controls). Peripheral blood samples from 66 medical workers exposed to low-dose ionising radiation and 89 non-exposed volunteers were collected for chromosome aberrations (CA) analysis and the cytokinesis-block micronucleus (CBMN) assay. Higher rates of chromatid and chromosome breaks, acentric fragments, double minutes, micronuclei, and micronucleated binuclear cells were observed in the control group, while the rate of nucleoplasmic bridges was higher in the medical workers group.
随着现代设备和防护措施的应用，医疗辐射照射已显著减少。对医务人员进行生物监测可以提供有关辐射照射可能影响的信息。然而，只有当估计有效剂量达到 200mSv 或更高时，才建议进行染色体畸变 (CA) 分析。在波斯尼亚和黑塞哥维那的这项回顾性研究中，我们测量了医务人员和健康志愿者（对照组）的细胞遗传学状况。采集了 66 名接触低剂量电离辐射的医务人员和 89 名未接触志愿者的外周血样本，用于染色体畸变 (CA) 分析和胞质分裂微核 (CBMN) 测定。在对照组中观察到较高的染色单体和染色体断裂、无着丝粒片段、双微体、微核和双核微核细胞的发生率，而在医务人员组中核质桥的发生率更高。
