Muraki T, Kato R
Pharmacol Biochem Behav. 1987 May;27(1):87-91. doi: 10.1016/0091-3057(87)90481-3.
The degree of hypothermia elicited by morphine was greater in DBA/2 than C57BL/6 strain mice of both sexes. Hypothermia elicited by morphine was antagonized by naloxone in both strains of mice, suggesting the involvement of opioid receptors. To examine the role of genetic factors in the strain difference of morphine-induced hypothermia, the effect of morphine on changes in the rectal temperature was studied in the 6 generations of male mice, including the 2 inbred strains, P1 (DBA/2) and P2 (C57BL/6), their F1 and F2 hybrids, and 2 backcrosses, B1 (F1 X P1) and B2 (F1 X P2). The order of mean temperature decrease determined 40 min after 20 mg/kg morphine injection was P1 greater than B1 greater than F1 = F2 greater than B2 greater than P2. There was no maternal effect on the morphine responses of the F1 generation. Biometrical analysis revealed that DBA/2 (P1) is partially dominant over C57BL/6 (P2) and contribution of polygenes was suggested.
吗啡引起的体温过低在DBA/2小鼠中比在两种性别的C57BL/6品系小鼠中更明显。吗啡引起的体温过低在两种品系小鼠中均被纳洛酮拮抗，提示阿片受体参与其中。为研究遗传因素在吗啡诱导体温过低品系差异中的作用，在6代雄性小鼠中研究了吗啡对直肠温度变化的影响，包括2个近交系P1（DBA/2）和P2（C57BL/6）、它们的F1和F2杂种以及2个回交系B1（F1×P1）和B2（F1×P2）。注射20mg/kg吗啡40分钟后测定的平均体温下降顺序为P1＞B1＞F1 = F2＞B2＞P2。母本对F1代的吗啡反应没有影响。生物统计学分析显示DBA/2（P1）对C57BL/6（P2）呈部分显性，并提示多基因的作用。
