Roy A, Guthrie S, Pickar D, Linnoila M
Psychiatry Res. 1987 Jun;21(2):161-8. doi: 10.1016/0165-1781(87)90073-4.
Thirty depressed patients were compared with 39 controls for their plasma norepinephrine (NE) levels in relation to a cold challenge (placing a hand in ice cold water for 1 minute). Depressed patients showed significantly higher plasma NE levels than controls. Unipolar, but not bipolar patients, had significantly higher plasma NE levels than age- and sex-matched controls. Unipolar melancholic patients who were nonsuppressors on the dexamethasone suppression test showed a strong trend to have higher plasma NE levels than suppressors. These results are further evidence that the NE system is dysregulated in depression.
将30名抑郁症患者与39名对照组进行比较，观察他们在冷刺激（将手放入冰水中1分钟）下的血浆去甲肾上腺素（NE）水平。抑郁症患者的血浆NE水平显著高于对照组。单相抑郁症患者而非双相情感障碍患者的血浆NE水平显著高于年龄和性别匹配的对照组。地塞米松抑制试验中无抑制反应的单相抑郁性患者，其血浆NE水平高于有抑制反应者的趋势明显。这些结果进一步证明抑郁症患者去甲肾上腺素系统失调。
