RNA m6A 甲基化在脂质代谢中的作用。
The role of RNA m6A methylation in lipid metabolism.
机构信息
Department of Endocrinology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Orthopaedics, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, China.
出版信息
Front Endocrinol (Lausanne). 2022 Sep 8;13:866116. doi: 10.3389/fendo.2022.866116. eCollection 2022.
The m6A methylation is the most numerous modification of mRNA in mammals, coordinated by RNA m6A methyltransferases, RNA m6A demethylases, and RNA m6A binding proteins. They change the RNA m6A methylation level in their specific manner. RNA m6A modification has a significant impact on lipid metabolic regulation. The "writer" METTL3/METTL14 and the "eraser" FTO can promote the accumulation of lipids in various cells by affecting the decomposition and synthesis of lipids. The "reader" YTHDF recognizes m6A methylation sites of RNA and regulates the target genes' translation. Due to this function that regulates lipid metabolism, RNA m6A methylation plays a pivotal role in metabolic diseases and makes it a great potential target for therapy.
m6A 甲基化是哺乳动物 mRNA 中最丰富的修饰，由 RNA m6A 甲基转移酶、RNA m6A 去甲基酶和 RNA m6A 结合蛋白协调。它们以特定的方式改变 RNA m6A 甲基化水平。RNA m6A 修饰对脂质代谢调节有重要影响。“写入器”METTL3/METTL14 和“橡皮擦”FTO 可以通过影响脂质的分解和合成，促进各种细胞中脂质的积累。“读取器”YTHDF 识别 RNA 的 m6A 甲基化位点，并调节靶基因的翻译。由于这种调节脂质代谢的功能，RNA m6A 甲基化在代谢性疾病中起着关键作用，使其成为治疗的潜在重要靶点。
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