Villavicencio R, Sánchez-Rosetti J
P R Health Sci J. 1987 Apr;6(1):7-12.
Kawasaki disease is a newly recognized clinical entity of unknown origin that occurs in the pediatric age and is characterized by multisystemic involvement. Pathologically, widespread vasculitis is present and approximately 10 to 20% of affected children have coronary aneurysms. The latter are mostly silent but 1-2% of them progress to coronary artery obstruction and death from myocardial infarction. Such aneurysms can be visualized by echocardiography and 50% of them apparently resolve, although in some cases, residual coronary artery damage persists after resolution of the aneurysm. The local experience with 116 patients of KD is reported. In only 4 of them significant coronary artery involvement was present. They all remained asymptomatic, the affected arteries were slowly recovering and no fatalities were present. The low incidence of coronary aneurysms and the uneventful course of the disease suggests a milder, less virulent course of KD in our environment. Residual changes in the affected coronary arteries are considered a late risk factor for coronary artery disease in man.
川崎病是一种新发现的病因不明的临床病症，发生于儿童期，其特征为多系统受累。病理上，存在广泛的血管炎，约10%至20%的患病儿童有冠状动脉瘤。后者大多无症状，但其中1%至2%会进展为冠状动脉阻塞并死于心肌梗死。此类动脉瘤可通过超声心动图显示，其中50%显然会消退，不过在某些情况下，动脉瘤消退后仍会残留冠状动脉损伤。报告了当地116例川崎病患者的情况。其中仅有4例存在显著的冠状动脉受累。他们均无症状，受累动脉在缓慢恢复，且无死亡病例。冠状动脉瘤的低发病率以及疾病的平稳病程表明，在我们所处的环境中，川崎病的病程较为温和、致病性较低。受累冠状动脉的残留改变被认为是人类冠状动脉疾病的晚期危险因素。
