Medical Imaging Key Laboratory of Sichuan Province, Department of Radiology, Medical Research Center, The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
Department of Radiology, People's Hospital of Deyang City, Deyang 618000, Sichuan Province, China.
World J Gastroenterol. 2022 Jul 21;28(27):3334-3345. doi: 10.3748/wjg.v28.i27.3334.
The morbidity and mortality of hepatocellular carcinoma (HCC) rank 6 and 4, respectively, among malignant tumors worldwide. Traditional diffusion-weighted imaging (DWI) uses the apparent diffusion coefficient (ADC) obtained by applying the monoexponential model to reflect water molecule diffusion in active tissue; however, the value of ADC is affected by microcirculation perfusion. Using a biexponential model, intravoxel incoherent motion (IVIM)-DWI quantitatively measures information related to pure water molecule diffusion and microcirculation perfusion, thus compensating for the shortcomings of DWI. The number of studies examining the application of IVIM-DWI in patients with HCC has gradually increased over the last few years, and many results show that IVIM-DWI has vital value for HCC differentiation, pathological grading, and predicting and evaluating the treatment response. The present study principally reviews the principle of IVIM-DWI and its research progress in HCC differentiation, pathological grading, predicting and evaluating the treatment response, predicting postoperative recurrence and predicting gene expression prediction.
肝细胞癌（HCC）的发病率和死亡率在全球恶性肿瘤中分别位居第 6 位和第 4 位。传统的弥散加权成像（DWI）采用单指数模型获得的表观扩散系数（ADC）来反映活性组织中水分子的扩散；然而，ADC 值受微循环灌注的影响。双指数模型的体素内不相干运动（IVIM）-DWI 定量测量与纯水分子扩散和微循环灌注相关的信息，从而弥补了 DWI 的不足。近年来，研究 IVIM-DWI 在 HCC 患者中的应用的研究逐渐增多，许多研究结果表明 IVIM-DWI 在 HCC 的鉴别诊断、病理分级、预测和评估治疗反应方面具有重要价值。本研究主要综述了 IVIM-DWI 的原理及其在 HCC 鉴别诊断、病理分级、预测和评估治疗反应、预测术后复发和预测基因表达预测方面的研究进展。
