Muco Erind, Patail Haris, Shaik Ayesha, McMahon Sean
Internal Medicine, University of Connecticut School of Medicine, Farmington, USA.
Cardiology, Hartford Hospital, Hartford, USA.
Cureus. 2022 Aug 19;14(8):e28184. doi: 10.7759/cureus.28184. eCollection 2022 Aug.
Capecitabine is a prodrug of fluorouracil that specifically targets cancer cells, commonly used as monotherapy for metastatic breast and colorectal cancer. Its side effects include nausea, diarrhea, vomiting, abdominal pain, anorexia, palmar-plantar erythrodysesthesia, anemia, and hyperbilirubinemia. Rarely, this chemotherapy agent has been associated with cardiotoxicity, including cardiac arrest, likely secondary to coronary vasospasm. This case report serves to highlight the unfortunate case of a 32-year-old female who suffered a ventricular fibrillation cardiac arrest three days after initiating capecitabine therapy.
卡培他滨是氟尿嘧啶的前体药物，可特异性靶向癌细胞，常用于转移性乳腺癌和结直肠癌的单药治疗。其副作用包括恶心、腹泻、呕吐、腹痛、厌食、手足红斑感觉异常、贫血和高胆红素血症。这种化疗药物很少与心脏毒性相关，包括心脏骤停，可能继发于冠状动脉痉挛。本病例报告旨在突出一名32岁女性在开始卡培他滨治疗三天后发生心室颤动心脏骤停这一不幸案例。
