二甲基亚砜（DMSO）对[具体对象]寿命和生理的影响：关于将DMSO用作化合物递送溶剂的意义。
Effect of DMSO on lifespan and physiology in : Implications for use of DMSO as a solvent for compound delivery.
作者信息
AlOkda Abdelrahman, Van Raamsdonk Jeremy M
机构信息
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Metabolic Disorders and Complications Program, and Brain Repair and Integrative Neuroscience Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada.
出版信息
MicroPubl Biol. 2022 Sep 7;2022. doi: 10.17912/micropub.biology.000634. eCollection 2022.
Dimethyl sulfoxide (DMSO) is a solvent that has been used for basic and medical research based on its ability to dissolve both polar and non-polar compounds. In order to use DMSO to deliver compounds that may impact longevity or neurodegeneration, it is important to first determine the effects of DMSO on aging and physiology. We examined the effect of different concentrations of DMSO on lifespan and development time in We found that DMSO concentrations up to 2% DMSO did not affect longevity in wild-type worms, while concentrations of up to 0.5% DMSO were compatible with normal development times. 0.5% DMSO also had minimal effect on fertility and movement. In summary, our results show that concentrations of DMSO up to 0.5% can be safely used to deliver compounds to with little or no modifying effects on lifespan or physiologic rates.
二甲基亚砜（DMSO）是一种溶剂，因其能够溶解极性和非极性化合物而被用于基础研究和医学研究。为了使用二甲基亚砜来递送可能影响寿命或神经退行性变的化合物，首先确定二甲基亚砜对衰老和生理的影响很重要。我们研究了不同浓度的二甲基亚砜对秀丽隐杆线虫寿命和发育时间的影响。我们发现，高达2%的二甲基亚砜浓度不会影响野生型线虫的寿命，而高达0.5%的二甲基亚砜浓度与正常发育时间相符。0.5%的二甲基亚砜对生育力和运动也有最小的影响。总之，我们的结果表明，高达0.5%的二甲基亚砜浓度可安全用于向秀丽隐杆线虫递送化合物，对寿命或生理速率几乎没有或没有修饰作用。
Zotero 插件