Murata T, Takahashi T
Radioisotopes. 1987 Apr;36(4):169-75. doi: 10.3769/radioisotopes.36.4_169.
This paper describes the biological radiation effects of carbon-14 and tritium labeled 5-fluorouracils (5-FU) which were given intraperitoneally at reasonable dose (14C: 1.85 MBq/kg (0.05 microCi/kg), 3H: 3.7 MBq/kg (0.1 microCi/kg)) and its forty times dose once a day for 3 days in mice. The results indicated that the change of body weight, urine and feces volume and its radioactivity, and organ weight and its residual radioactivity except pancreas were not observed any significant difference between three groups of both 14C and 3H, but white blood cell number markedly decreased proportionally with radioisotope dose of both 14C and 3H and also red blood cell number decreased by [6-3H]-5-FU 148 MBq/kg i.p. The results suggest that high level radioisotope dose of both 14C and 3H 5-FUs have no biological radiation effects on the studies of drug metabolism in vivo, however that in the case of hematogenic organ, the biological radiation effect is not disregarded.
本文描述了以合理剂量（碳-14：1.85 兆贝可/千克（0.05 微居里/千克），氚：3.7 兆贝可/千克（0.1 微居里/千克））腹腔注射碳-14 和氚标记的 5-氟尿嘧啶（5-FU）及其 40 倍剂量，每天一次，连续 3 天对小鼠产生的生物辐射效应。结果表明，碳-14 和氚的三组实验中，体重、尿液和粪便体积及其放射性、除胰腺外的器官重量及其残留放射性均未观察到显著差异，但白细胞数量随碳-14 和氚的放射性同位素剂量成比例显著下降，并且腹腔注射 148 兆贝可/千克的[6-氚]-5-FU 后红细胞数量也减少。结果表明，高剂量的碳-14 和氚标记的 5-FU 对体内药物代谢研究没有生物辐射效应，然而对于造血器官而言，生物辐射效应不容忽视。
