Pedersen N T, Marqversen J
Eur J Nucl Med. 1981;6(7):327-9. doi: 10.1007/BF00262527.
To estimate the radiation dose of ingested 14C- (and 3H-) labelled fatty acids, we measured 14CO2 in samples of expired air in five subjects, and serum 14C activity in four subjects, over 4 weeks. These investigations showed that 25%-40% of ingested 14C-fatty acids were metabolized and expired as 14CO2 within 10 days after ingestion. The residue was expired with a calculated half-life of 493 days. Six days after ingestion of the radiolipids, radioactivity in serum was barely detectable. From these data of 14C-fatty acid metabolism, a total whole-body radiation of 20 mrem/microCi 14C, 8 mrem/microCi 14C the first year, was calculated. The corresponding radiation dose for 3H-fatty acid was 2 mrem/microCi 3H and 1 mrem/microCi 3H respectively. Maximal organ-specific radiation (gonads and lungs) from the blood-borne radioactivity was 1 mrem/microCi of 14C-fatty acid.
为估算摄入的14C-（和3H-）标记脂肪酸的辐射剂量，我们在4周内测量了5名受试者呼出气体样本中的14CO2以及4名受试者血清中的14C活性。这些研究表明，摄入的14C-脂肪酸在摄入后10天内有25%-40%被代谢并以14CO2的形式呼出。残留物的呼出半衰期经计算为493天。摄入放射性脂质6天后，血清中的放射性几乎检测不到。根据这些14C-脂肪酸代谢数据，计算出全身总辐射量为每微居里14C 20毫雷姆，第一年为每微居里14C 8毫雷姆。3H-脂肪酸的相应辐射剂量分别为每微居里3H 2毫雷姆和每微居里3H 1毫雷姆。血源性放射性物质产生的最大器官特异性辐射（性腺和肺部）为每微居里14C-脂肪酸1毫雷姆。
