Biagini C, Campodonico F, Maurizi Enrici R
Radiol Med. 1987 Jul-Aug;74(1-2):1-12.
The possibilities of utilizing Nuclear Magnetic Resonance in Radiation Oncology are examined, on the basis of information provided by spectroscopy (MRS), studies on the tissues characterization of tumors, and preliminary practical application of imaging (MRI) to radiation therapy. MRS affords information on the bioenergetics of the tumor cells, and on the biochemical changes induced by ionizing radiation; further, some results of clinical importance were obtained in "monitoring" tumor response to radiation therapy and chemotherapy. Tissue characterization of normal tissues and of tumor is analyzed; technical factors, morphological elements, and structural elements are considered. Morphological elements include anatomical recognition, clinical and radiological evaluation, appraisal of the peritumoral tissues, and analysis of inhomogeneities. Among structural elements are considered some methods suitable to achieve a full evaluation of tissue characterization of tumors, on the basis of an appropriate employment of sequence parameters. Practical application of MRI on radiotherapy of tumors comprises staging procedures, contribution to the selection of differentiated radiation volumes for radiotherapy planning, and new data on the evaluation of biological effects of ionizing radiation on normal tissues of patients.
基于磁共振波谱学（MRS）提供的信息、肿瘤组织特征研究以及成像（MRI）在放射治疗中的初步实际应用，对核磁共振在放射肿瘤学中的应用可能性进行了研究。MRS可提供有关肿瘤细胞生物能量学以及电离辐射诱导的生化变化的信息；此外，在“监测”肿瘤对放射治疗和化疗的反应方面还获得了一些具有临床意义的结果。对正常组织和肿瘤的组织特征进行了分析；考虑了技术因素、形态学要素和结构要素。形态学要素包括解剖学识别、临床和放射学评估、瘤周组织评估以及不均匀性分析。在结构要素中，考虑了一些基于序列参数的适当应用来全面评估肿瘤组织特征的方法。MRI在肿瘤放射治疗中的实际应用包括分期程序、对放疗计划中不同照射体积选择的贡献，以及关于电离辐射对患者正常组织生物学效应评估的新数据。
