眼科中鼻眶毛霉菌病管理的挑战与陷阱：COVID-19时代的一个突出问题
Challenges and Pitfalls in the Management of Rhino-Orbital Mucormycosis in Ophthalmology: A Highlighted Problem in the COVID-19 Era.
作者信息
Pakdel Farzad, Zand Amin, Sharifi Ali, Asadi Masih, Abri Aghdam Kaveh
机构信息
Department of Oculo-Facial Plastic Surgery, Department of Ophthalmology, Farabi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Ophthalmology, Shafa Hospital, Kerman University of Medical Sciences, Kerman, Iran.
出版信息
J Ophthalmic Vis Res. 2022 Aug 15;17(3):424-431. doi: 10.18502/jovr.v17i3.11582. eCollection 2022 Jul-Sep.
Abstract
Secondary infections in hospitalized and ill patients with coronavirus disease 2019 (COVID-19) are common. One of these life-threatening infectious diseases is rhino-orbital mucormycosis, which made an outbreak recently. This outbreak was mainly caused by the administration of high-dose corticosteroids in patients with COVID-19, especially those with diabetes mellitus. The increased incidence of rhino-orbital mucormycosis in the COVID-19 era presents different challenges for healthcare providers including ophthalmologists who are directly involved in disease management. We summarized the main challenges and recommendations for ophthalmologists on the management of rhino-orbital mucormycosis.
摘要
2019冠状病毒病（COVID-19）住院患者和患病患者的继发感染很常见。其中一种危及生命的传染病是鼻眶毛霉病，该病最近爆发。此次爆发主要是由COVID-19患者，尤其是糖尿病患者使用大剂量皮质类固醇引起的。COVID-19时代鼻眶毛霉病发病率的增加给包括直接参与疾病管理的眼科医生在内的医疗服务提供者带来了不同的挑战。我们总结了眼科医生在鼻眶毛霉病管理方面的主要挑战和建议。
相似文献
1
Challenges and Pitfalls in the Management of Rhino-Orbital Mucormycosis in Ophthalmology: A Highlighted Problem in the COVID-19 Era.眼科中鼻眶毛霉菌病管理的挑战与陷阱：COVID-19时代的一个突出问题
J Ophthalmic Vis Res. 2022 Aug 15;17(3):424-431. doi: 10.18502/jovr.v17i3.11582. eCollection 2022 Jul-Sep.
2
Increased incidence of rhino-orbital mucormycosis in an educational therapeutic hospital during the COVID-19 pandemic in western Iran: An observational study.在伊朗西部 COVID-19 大流行期间，一所教学治疗医院中鼻-眶-脑毛霉菌病发病率的增加：一项观察性研究。
Mycoses. 2021 Nov;64(11):1366-1377. doi: 10.1111/myc.13351. Epub 2021 Jul 31.
3
Epidemiology, clinical profile, management, and outcome of COVID-19-associated rhino-orbital-cerebral mucormycosis in 2826 patients in India - Collaborative OPAI-IJO Study on Mucormycosis in COVID-19 (COSMIC), Report 1.印度 2826 例 COVID-19 相关的鼻-眶-脑毛霉菌病的流行病学、临床特征、治疗和结局 - 合作 OPAI-IJO 新冠病毒相关毛霉菌病研究（COSMIC），报告 1。
Indian J Ophthalmol. 2021 Jul;69(7):1670-1692. doi: 10.4103/ijo.IJO_1565_21.
4
Rhino-Orbital Cerebral Mucormycosis in a Non-diabetic Patient Following COVID-19 Infection: A Case Report and Literature Review.1例COVID-19感染后非糖尿病患者的鼻-眶-脑毛霉菌病：病例报告及文献复习
Cureus. 2022 Dec 23;14(12):e32884. doi: 10.7759/cureus.32884. eCollection 2022 Dec.
5
COVID-19 associated rhino-orbital-cerebral mucormycosis-an institutional series.COVID-19 相关的鼻眶脑毛霉菌病——一项机构系列研究。
Ear Nose Throat J. 2024 Jun;103(1_suppl):134S-144S. doi: 10.1177/01455613221077882. Epub 2022 Feb 18.
6
Rhino-orbital mucormycosis following COVID-19 in previously non-diabetic, immunocompetent patients.COVID-19 相关的非糖尿病、免疫功能正常患者的鼻眶脑毛霉菌病。
Orbit. 2021 Dec;40(6):499-504. doi: 10.1080/01676830.2021.1960382. Epub 2021 Aug 1.
7
Rhino-orbital-cerebral mucormycosis as a complication of coronavirus disease 2019.鼻眶脑型毛霉菌病作为2019冠状病毒病的一种并发症
World J Virol. 2022 Sep 25;11(5):293-299. doi: 10.5501/wjv.v11.i5.293.
8
Is mucormycosis the end? A comprehensive management of orbit in COVID associated rhino-orbital-cerebral mucormycosis: preserving the salvageable.是否意味着毛霉菌病的终结？COVID 相关的鼻-眶-脑毛霉菌病的全面管理：保留可挽救的。
Eur Arch Otorhinolaryngol. 2023 Feb;280(2):819-827. doi: 10.1007/s00405-022-07620-3. Epub 2022 Sep 2.
9
Rise of the phoenix: Mucormycosis in COVID-19 times.凤凰涅槃：新冠时期的毛霉菌病。
Indian J Ophthalmol. 2021 Jun;69(6):1563-1568. doi: 10.4103/ijo.IJO_310_21.
10
Prevalence, predictors, and outcome of pulmonary mucormycosis in COVID-19 associated rhino orbital mucormycosis in a tertiary care center in South India.印度南部一家三级护理中心中，新冠病毒相关鼻眶毛霉病患者的肺部毛霉病患病率、预测因素及预后情况
Curr Med Mycol. 2023 Sep;9(3):33-37. doi: 10.22034/cmm.2023.345154.1486.
引用本文的文献
1
Necrotizing orbital infections: A comprehensive review.坏死性眼眶感染：全面综述
Saudi J Ophthalmol. 2025 Jun 25;39(2):128-140. doi: 10.4103/sjopt.sjopt_87_25. eCollection 2025 Apr-Jun.
2
Oculoplastic Conditions in Covid-19 Patients: Case Series and Literature Review.新冠病毒感染患者的眼部整形病症：病例系列及文献综述
J Ophthalmic Vis Res. 2024 Jun 21;19(2):235-245. doi: 10.18502/jovr.v19i2.10908. eCollection 2024 Apr-Jun.
3
Neuro-ophthalmic Manifestations of Coronavirus Disease 2019 and Its Vaccination: A Narrative Review.2019冠状病毒病及其疫苗接种的神经眼科表现：一项叙述性综述
J Ophthalmic Vis Res. 2023 Feb 21;18(1):113-122. doi: 10.18502/jovr.v18i1.12731. eCollection 2023 Jan-Mar.
4
Perioperative Challenges in the Management of Rhino-Orbital Cerebral Mucormycosis: An Observational Study from a Tertiary Care Hospital.鼻眶脑型毛霉菌病管理中的围手术期挑战：来自三级护理医院的一项观察性研究
Anesth Essays Res. 2022 Jul-Sep;16(3):331-335. doi: 10.4103/aer.aer_83_22. Epub 2022 Dec 9.
本文引用的文献
1
Mucormycosis: The hidden and forgotten disease.毛霉菌病：被忽视的隐匿性疾病。
J Appl Microbiol. 2022 Jun;132(6):4042-4057. doi: 10.1111/jam.15487. Epub 2022 Feb 23.
2
Global Prevalence of COVID-19-Associated Mucormycosis (CAM): Living Systematic Review and Meta-Analysis.新型冠状病毒肺炎相关毛霉菌病（CAM）的全球患病率：实时系统评价与荟萃分析
J Fungi (Basel). 2021 Nov 18;7(11):985. doi: 10.3390/jof7110985.
3
Mycotic infections - mucormycosis and oral candidiasis associated with Covid-19: a significant and challenging association.霉菌感染——毛霉病和与新冠病毒相关的口腔念珠菌病：一种重要且具有挑战性的关联。
J Oral Microbiol. 2021 Aug 26;13(1):1967699. doi: 10.1080/20002297.2021.1967699. eCollection 2021.
4
Mucormycosis and COVID-19: An epidemic within a pandemic in India.毛霉菌病与 COVID-19：印度大流行中的一场流行病。
Mycoses. 2021 Oct;64(10):1253-1260. doi: 10.1111/myc.13353. Epub 2021 Jul 24.
5
Mucormycosis in COVID-19: A systematic review of cases reported worldwide and in India.COVID-19 相关毛霉菌病：全球及印度病例报告的系统综述。
Diabetes Metab Syndr. 2021 Jul-Aug;15(4):102146. doi: 10.1016/j.dsx.2021.05.019. Epub 2021 May 21.
6
Molecular identification and clinical features of fungal rhinosinusitis: A 3-year experience with 108 patients.真菌性鼻窦炎的分子鉴定和临床特征：3 年 108 例患者的经验。
Microb Pathog. 2021 Sep;158:105018. doi: 10.1016/j.micpath.2021.105018. Epub 2021 Jun 16.
7
Mucormycosis in patients with COVID-19: A cross-sectional descriptive multicentre study from Iran.COVID-19 患者中的毛霉菌病：来自伊朗的一项横断面描述性多中心研究。
Mycoses. 2021 Oct;64(10):1238-1252. doi: 10.1111/myc.13334. Epub 2021 Jul 1.
8
Rhino-orbital-cerebral mucormycosis (ROCM) and associated cerebritis treated with adjuvant retrobulbar amphotericin B.采用球后注射两性霉素B辅助治疗鼻眶脑型毛霉菌病（ROCM）及相关脑炎。
Am J Ophthalmol Case Rep. 2020 Jun 6;19:100771. doi: 10.1016/j.ajoc.2020.100771. eCollection 2020 Sep.
9
Global Epidemiology of Mucormycosis.毛霉病的全球流行病学
J Fungi (Basel). 2019 Mar 21;5(1):26. doi: 10.3390/jof5010026.
10
Mucormycosis: Battle with the Deadly Enemy over a Five-Year Period in India.毛霉病：印度五年间与致命敌人的斗争
J Fungi (Basel). 2018 Apr 6;4(2):46. doi: 10.3390/jof4020046.
Zotero 插件