病毒感染和细胞应激期间RNA聚合酶II亚基的调节

RNA polymerase II subunit modulation during viral infection and cellular stress.

作者信息

Gulyas Leah, Glaunsinger Britt A

机构信息

Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA.

Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA; Howard Hughes Medical Institute, University of California, Berkeley, CA 94709, USA.

出版信息

Curr Opin Virol. 2022 Oct;56:101259. doi: 10.1016/j.coviro.2022.101259. Epub 2022 Sep 23.

DOI:10.1016/j.coviro.2022.101259

PMID:36162260

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10150648/

Abstract

Control of gene expression, including transcription, is central in dictating the outcome of viral infection. One of the profound alterations induced by viruses is modification to the integrity and function of eukaryotic RNA polymerase II (Pol II). Here, we discuss how infection perturbs the Pol II complex by altering subunit phosphorylation and turnover, as well as how cellular genotoxic stress (e.g. DNA damage) elicits similar outcomes. By highlighting emerging parallels and differences in Pol II control during viral infection and abiotic stress, we hope to bolster identification of pathways that target Pol II and regulate the transcriptome.

摘要

基因表达的调控，包括转录，在决定病毒感染的结果中起着核心作用。病毒诱导的一个深刻变化是对真核RNA聚合酶II（Pol II）的完整性和功能的修饰。在这里，我们讨论感染如何通过改变亚基磷酸化和周转来扰乱Pol II复合物，以及细胞遗传毒性应激（如DNA损伤）如何引发类似的结果。通过强调病毒感染和非生物应激期间Pol II调控中出现的相似之处和差异，我们希望加强对靶向Pol II并调节转录组的途径的识别。