至关重要但又脆弱不堪：人类 TRPV6 是强大的钙摄取能力和易患上皮屏障功能障碍的权衡。

Vital but vulnerable: Human TRPV6 is a trade-off of powerful Ca uptake and susceptibility to epithelial barrier dysfunction.

机构信息

Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.

出版信息

Cell Calcium. 2022 Nov;107:102652. doi: 10.1016/j.ceca.2022.102652. Epub 2022 Sep 13.

DOI:10.1016/j.ceca.2022.102652

PMID:36162385

Abstract

Robust Ca absorption is controlled by the highly Ca-permeable channels TRPV5 and TRPV6 in the kidney and intestine of terrestrial vertebrates, to fulfill the body's demand for Ca. Recently, a pathogenic role of TRPV6 was revealed in alcohol-associated endotoxemia; the intestinal barrier function is compromised by oxidative stress via TRPV6-mediated Ca dysregulation. TRPV6-mediated Ca absorption vital to maintain homeostasis is vulnerable to alcohol-induced malactivation.

摘要

钙的吸收由陆生脊椎动物肾脏和肠道中高渗透性钙通道 TRPV5 和 TRPV6 控制，以满足身体对钙的需求。最近，TRPV6 在酒精相关内毒素血症中发挥致病作用的机制被揭示：氧化应激通过 TRPV6 介导的钙失调损害肠道屏障功能。TRPV6 介导的对维持体内平衡至关重要的钙吸收易受到酒精诱导的过度激活的影响。