Pin1 与阿尔茨海默病。
Pin1 and Alzheimer's disease.
机构信息
Department of Pathology, UT Southwestern Medical Center, 5333 Harry Hines Blvd, Dallas, TX 75390.
出版信息
Transl Res. 2023 Apr;254:24-33. doi: 10.1016/j.trsl.2022.09.003. Epub 2022 Sep 23.
Abstract
Alzheimer's disease (AD) is an immense and growing public health crisis. Despite over 100 years of investigation, the etiology remains elusive and therapy ineffective. Despite current gaps in knowledge, recent studies have identified dysfunction or loss-of-function of Pin1, a unique cis-trans peptidyl prolyl isomerase, as an important step in AD pathogenesis. Here I review the functionality of Pin1 and its role in neurodegeneration.
摘要
阿尔茨海默病（AD）是一个巨大且日益严重的公共健康危机。尽管已经进行了 100 多年的研究，但病因仍然难以捉摸，治疗效果也不佳。尽管目前还存在知识上的差距，但最近的研究已经确定了 Pin1 的功能障碍或失活，Pin1 是一种独特的顺式-反式肽基脯氨酰异构酶，是 AD 发病机制中的一个重要步骤。在这里，我回顾了 Pin1 的功能及其在神经退行性变中的作用。
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