Kim Hyeon Soo, Jung Haram, Park Yong Ho, Heo Su-Hak, Kim Sujin, Moon Minho
Department of Biochemistry, College of Medicine, Konyang University, Daejeon 35365, Korea.
Department of Medicinal Bioscience, Konkuk University (Glocal Campus), Chungcheongbuk-do 27478, Korea.
Aging Dis. 2024 Apr 6;16(2):901-916. doi: 10.14336/AD.2024.0406.
The dynamic interaction between the brain and the skin is termed the 'skin-brain axis.' Changes in the skin not only reflect conditions in the brain but also exert direct and indirect effects on the brain. Interestingly, the connection between the skin and brain is crucial for understanding aging and neurodegenerative diseases. Several studies have shown an association between Alzheimer's disease (AD) and various skin disorders, such as psoriasis, bullous pemphigoid, and skin cancer. Previous studies have shown a significantly increased risk of new-onset AD in patients with psoriasis. In contrast, skin cancer may reduce the risk of developing AD. Accumulating evidence suggests an interaction between skin disease and AD; however, AD-associated pathological changes mediated by the skin-brain axis are not yet clearly defined. While some studies have reported on the diagnostic implications of the skin-brain axis in AD, few have discussed its potential therapeutic applications. In this review, we address the pathological changes mediated by the skin-brain axis in AD. Furthermore, we summarize (1) the diagnostic implications elucidated through the role of the skin-brain axis in AD and (2) the therapeutic implications for AD based on the skin-brain axis. Our review suggests that a potential therapeutic approach targeting the skin-brain axis will enable significant advances in the treatment of AD.
大脑与皮肤之间的动态相互作用被称为“皮肤-脑轴”。皮肤的变化不仅反映大脑的状况，还会对大脑产生直接和间接的影响。有趣的是，皮肤与大脑之间的联系对于理解衰老和神经退行性疾病至关重要。多项研究表明，阿尔茨海默病（AD）与多种皮肤疾病有关，如银屑病、大疱性类天疱疮和皮肤癌。先前的研究表明，银屑病患者新发AD的风险显著增加。相反，皮肤癌可能会降低患AD的风险。越来越多的证据表明皮肤疾病与AD之间存在相互作用；然而，由皮肤-脑轴介导的AD相关病理变化尚未明确界定。虽然一些研究报道了皮肤-脑轴在AD中的诊断意义，但很少有研究讨论其潜在的治疗应用。在本综述中，我们阐述了皮肤-脑轴在AD中介导的病理变化。此外，我们总结了（1）通过皮肤-脑轴在AD中的作用所阐明的诊断意义，以及（2）基于皮肤-脑轴对AD的治疗意义。我们的综述表明，针对皮肤-脑轴的潜在治疗方法将使AD的治疗取得重大进展。
