下咽鳞状细胞癌中转录因子 c-Jun 的预后和临床病理意义：一项 3 年随访的回顾性研究。

Prognostic and clinicopathological significance of transcription factor c-Jun in hypopharyngeal squamous cell carcinoma: a 3-year follow-up retrospective study.

机构信息

Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, 200031, China.

Department of Pathology, Eye & ENT Hospital Fudan University, Shanghai, 200031, China.

出版信息

BMC Cancer. 2022 Sep 26;22(1):1019. doi: 10.1186/s12885-022-10113-5.

DOI:10.1186/s12885-022-10113-5

PMID:36163022

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9513886/

Abstract

PURPOSE

To investigate the expression and prognostic value of c-Jun in hypopharyngeal squamous cell carcinoma (HPSCC).

METHODS

A retrospective study was performed on a cohort of 99 HPSCC patients. The expression of c-Jun and phosphorylated-c-Jun (p-c-Jun) was evaluated via immunohistochemistry (IHC) staining. Overall survival (OS) and progression-free survival (PFS) were assessed using Kaplan-Meier method and multivariate Cox regression analysis.

RESULTS

The high expression of c-Jun and p-c-Jun in HPSCC accounted for 60.61% and 16.16%, respectively. High expression of c-Jun was closely associated with cT stage (p = 0.0401), tumor size (p = 0.0276), number of lymph node metastases (p = 0.0205) and pathological differentiation (p = 0.0108). The expression of c-Jun (p = 0.0043), p-c-Jun (p = 0.0376) and c-Jun/p-c-Jun were closely associated with poor OS. The Cox proportional multivariate hazard model revealed that lymphovascular invasion and c-Jun expression were independent influencing factors of OS in HPSCC patients.

CONCLUSION

Our findings suggest that c-Jun is a reliable prognostic factors in HPSCC patients.

摘要

目的

研究 c-Jun 在下咽鳞癌（HPSCC）中的表达及其预后价值。

方法

对 99 例 HPSCC 患者进行回顾性研究。采用免疫组织化学（IHC）染色法检测 c-Jun 和磷酸化-c-Jun（p-c-Jun）的表达。采用 Kaplan-Meier 法和多因素 Cox 回归分析评估总生存（OS）和无进展生存（PFS）。

结果

HPSCC 中 c-Jun 和 p-c-Jun 的高表达分别占 60.61%和 16.16%。c-Jun 的高表达与 cT 分期（p = 0.0401）、肿瘤大小（p = 0.0276）、淋巴结转移数（p = 0.0205）和病理分化（p = 0.0108）密切相关。c-Jun（p = 0.0043）、p-c-Jun（p = 0.0376）和 c-Jun/p-c-Jun 的表达与 OS 不良密切相关。Cox 比例多因素风险模型显示，血管淋巴管侵犯和 c-Jun 表达是 HPSCC 患者 OS 的独立影响因素。