USP7和p53在晚期下咽癌中的预后价值。

The prognostic value of USP7 and p53 in advanced hypopharyngeal carcinoma.

作者信息

Sun Ji, Lin Lan, Zhang Jiahao, Hu Chunyan, Wang Jie

机构信息

Department of Pathology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China.

出版信息

Ann Diagn Pathol. 2021 Apr;51:151695. doi: 10.1016/j.anndiagpath.2020.151695. Epub 2021 Jan 5.

DOI:10.1016/j.anndiagpath.2020.151695

PMID:33460997

Abstract

BACKGROUND

Hypopharyngeal squamous cell carcinoma (HPSCC) is a rare malignancy of poor prognosis in head and neck. The aim of the study is to assess the expression and prognostic value of USP7 and p53 in advanced HPSCC.

METHODS

A retrospective study was performed on a cohort of 103 patients with advanced HPSCC. The immunohistochemical expression of USP7 and p53 was evaluated in all the patients, and the prognostic value of USP7 and p53 was further evaluated. Overall survival (OS), disease-free survival (DFS), distant metastasis-free survival (DMFS), and local-regional recurrence-free survival (LRFS) were assessed using the Kaplan-Meier method and multivariate Cox regression analysis.

RESULTS

In our study, 78 patients (75.7%) showed low expression of USP7, and the other 25 patients (24.3%) had high expression of USP7; additionally, high USP7 expression was associated with advanced T stage. Low expression of p53 was found in 52 patients (50.5%), while the other 51 patients (49.5%) had a high expression of p53. Our data revealed that low expression of p53 was associated with the advanced N stage (p=0.028). Kaplan-Meier analysis revealed that high expression of USP7 was significantly correlated with the inferior OS, DFS, DMFS, and LRFS, respectively (all p<0.05); additionally, high expression of p53 was correlated with superior OS (p=0.023). The Cox proportional multivariate hazard model revealed that high expression of USP7 was an independent predictor of poor OS, DFS, and LRFS, respectively (all p<0.05).

CONCLUSIONS

Our findings suggest that USP7 combined with p53 are reliable prognostic factors in patients with advanced HPSCC.

摘要

背景

下咽鳞状细胞癌（HPSCC）是头颈部一种预后较差的罕见恶性肿瘤。本研究旨在评估泛素特异性蛋白酶7（USP7）和p53在晚期HPSCC中的表达及预后价值。

方法

对103例晚期HPSCC患者进行回顾性研究。评估所有患者中USP7和p53的免疫组化表达，并进一步评估USP7和p53的预后价值。采用Kaplan-Meier法和多因素Cox回归分析评估总生存期（OS）、无病生存期（DFS）、无远处转移生存期（DMFS）和无局部区域复发生存期（LRFS）。

结果

在本研究中，78例患者（75.7%）显示USP7低表达，另外25例患者（24.3%）USP7高表达；此外，USP7高表达与晚期T分期相关。52例患者（50.5%）p53低表达，另外51例患者（49.5%）p53高表达。我们的数据显示，p53低表达与晚期N分期相关（p=0.028）。Kaplan-Meier分析显示，USP7高表达分别与较差的OS、DFS、DMFS和LRFS显著相关（均p<0.05）；此外，p53高表达与较好的OS相关（p=0.023）。Cox比例多因素风险模型显示，USP7高表达分别是OS、DFS和LRFS较差的独立预测因素（均p<0.05）。